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5 Cards in this Set

  • Front
  • Back
Typical Antipsychotics :High Potency
-2 Receptor actions
-High potency D2 antagonist
-Alpha1 antagonist
Typical Antipsychotics: Mid Potency
-4 Receptor action
-mid potency D2 antagonist
-alpha 1 antagonist
-H1 antagonist
-Muscarinic antagonist
Typical Antipsychotics: Low Potency
-Receptor action
-low potency D2 antagonist
-most potent muscarinic antagonist
Atypical Antipsychotics: Transmitter interaction Hypothesis
-State it
-All atypical antipsychotics are both D2 and 5HT-2A antagonists

-Blockade of 5HT-2A on DA cell bodies causes an INCREASE in DA release

-There are more 5HT-2A receptors in some areas than others
Atypical Antipsychotics: Transmitter interaction Hypothesis
-Effect in Cortex
-Effect in Striatum
-Effect in Pituitary
-Effect in Limbic System
Higher level of DA from block
-enhanced cognition, improvement in negative symptoms
-improvement in EPS
-Less prolactin release

Maintained D2 Block
-Improvement in positive symptoms