Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/10

Click to flip

10 Cards in this Set

  • Front
  • Back
ETOH Absorption
-Location
-Active or passive
-Rate in fasting state
-Factors on rate
-Small intestine>>stomach

-passive--> not saturable

-30 mins to peak BAL fasting

-[ETOH] of drink; food fat>CHO>protein; pattern of consumption
ETOH Distribution
-Volume of distribution
-Women vs Men
- 0.5-0.7L/kg ~total body water

- ETOH enters fat more slowly; women have more fat, thus less TBW, thus achieve higher BAL for the same dose
ETOH: Alcohol Dehydrogenase
-Product
-Kinetics
-Location
-Gender difference
-Polymorphism
-ETOH --> acetaldehyde

-1st order kinetics; saturated after BAL of 10-100 mg/dL

-Mainly in the liver; also in brain and stomach

-Men have higher stomach ADH activity

-Mutant lower ADH levels in Asians associated with higher risk of alcoholism
ETOH: MEOS
-Product
-Kinetics
-CYP levels
-Byproducts
MEOS: CYP 2E1

-ETOH --> acetaldehyde

-Zero order kinetics: MEOS kicks in when ADH is saturated

-CYP E21 upregulated in response to increased consumption --> basis for tolerance

-toxic byproducts
ETOH: Acetaldehyde Dehydrogenase
-Product
-Inhibitor
-Polymorphism
-acetaldehyde --> acetate --> CO + H2O

-inhibited by disulfuram
-Asians are ALDH deficient
-->both lead to flushing, vomiting and dizziness
ETOH: Max. BAL factors
-Vd
-Rate of absorption
-Rate of metabolism
?
ETOH: Chronic effects on CNS
-Loss of white and grey matter in the frontal lobe

-Reduced brain metabolism

-Wernicke's/Korsakoff

-Neuropathy (saturday night palsy)
ETOH: Acute and Chronic effects on CVS
Acute
-Vasodilation
-Reduced myocardial contractility
-Arrhythmias

Chronic
- increased BP
- dilated cardiomyopathy
- increased triglycerides
ETOH: Acute effects on kidney
-Decreases ADH secretion--> diuresis and kaluresis

- vasodilation leads to diuresis

- decreased uric acid excretion
ETOH: Acute and chronic effects on GI tract
Acute
- secretion of gastrin, pepsin, histamine, and acid --> all lead to peptic ulcer disease
-emesis

Chronic
-pancreatitis
-gastritis and esophageal cancers