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14 Cards in this Set

  • Front
  • Back
What are the four McGeers criteria for Neurotransmitters?
Anatomical -have regional specificity
Chemical
Physiological -should produce a physiologic response when administered
Pharmacological
2 mechanisms neural excitement can occur?
Depolarize (via Na ion channels)
Stimulate 2nd messenger systems
3 mechanisms that inhibition can occur?
Hyperpolarizing
Blocking 2nd messenger systems
Autoinhibition
What is autoinhibition?
A neurotransmitter activates a receptor which leads to decreased release of that neurotransmitter
What kind of neurotransmitters are GABA and Glutamate?
CNS Gamma Aminobutyric acid is inhibitory and glutamate is excitatory
How are Noradrenaline(NA or NE) and Dopamine(DA) related?
NA is a derivative of DA both are result of Tyrosine modification.
What are two other key CNS neurotransmitters?
Serotonin (5HT produced from Tryptophan)
Acetylcholine
Are these neurotransmitters excitatory or inhibitory?
Depends on the subtype of receptor and second messengers.
What is a fundamental principle of biologic Psychiatry?
Mental illness is due to disregulation of neurotransmission (too much or too little)
How can there be a functional excess of neurotransmitter?
-too much produced
-too much released
-too many receptors
-too sensitive receptors
-too much 2nd messenger activity
-faulty inactivation
What are some mechanisms of funcitonal deficiency of neurotransmitters?
-not enough transmitter produced
-nout enough transmitter released
-not enough receptors
-insensitive receptors
-ineffective 2nd messengers
-excessive inactivation
What are some charcteristics of Parkinson's Disease?
R- Rigidity
A -Akinesia/Bradykinesia
T -Tremor (Pill rolling)
S -Stooped shuffling gait
What is an underlying cause of Parkinson's?
Deficiency of dopamingergic neurons
What are four possible interventions (pharmacologic) for Parkinson's?
-give dopamine precursor (L Dopa)
-block degradation -MOA inhibitor
-give DA releasing agent (amitidine)
-give DA agonist