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6 Cards in this Set

  • Front
  • Back
Barbiturates Site of Action
-Effect of Structure
-Receptor Target
-Effect of Structure: lipophyllic structure allows easy access to CNS

-Receptor Target: enhances GABA-GABA-Receptor binding. Can increase chloride current to the point of totally depressing voltage gated Ca2+ currents-->cardiac ionotropy
Barbiturates
-CVS Effects
-Respiratory Effects
CVS Effects
- decreases BP: dangerous during shock and hemorrhage

Respiratory Effects
-Suppression of C02 response curve and hypoxic ventilatory drive
Barbiturates
-Administration/absorption
-Distribution
-Metabolism
Administration/absorption
-complete absorption with onset in under 30 minutes

Distribution
-Rapid. Large Vd

Metabolism
-p450 hepatic metabolism; can induce p450. Most have long half lives
Benzodiazepines
-6 major effects
1. sedation
2. hypnosis
3. anxiolysis
4. anticonvulsant
5. muscle relaxation
6. amnesia
Benzodiazepines
-CVS Effects
-Respiratory Effects
-safer than barbiturates; death from pure benzodiazepine overdose is rare

CVS Effects
-mild decrease in BP

Respiratory Effects
-mild decrease in initiation of respiration
Benzodiazepines
-Receptor binding
-effect on current
- Binds to GABA-chlorid recptor and increases Cl current when GABA is bound.

-Hyperpolarizes membrane but with a ceiling effect