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11 Cards in this Set
- Front
- Back
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what is the primary function of the basal ganglia?
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-to coordinate motor activity with the cerebellum
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what do we find in the striatum?
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-medium spiny neurons expressing the D1 receptor
-GABA associated with substance P and dynorphin |
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what do we find in the matrix?
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-medium spiny neurons expressing the D2 receptor
-GABA associated with encephalin |
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what do giant aspiny neurons use as their NT?
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-ACh
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what does the dorsal striatum include?
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-caudate and putamen
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what is the effect of dopamine at D1 and D2 receptors?
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-D1 inc resting neuronal activity
-D2 dec resting activity |
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what is the net effect of the direct pathway?
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-inhibits the thalamic inhibition
-results in a net inc in thalamic activity |
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where does the direct pathway start and end?
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-goes directly from the striatum to the GPi/SNpr
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what is the net effect of the indirect pathway?
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-dec in thalamic activity
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what are hypokinetic disorders?
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-where the SNpc has diminished or no significant release of DA into the striatum
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what are choreiform disorders?
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-deficiency in the amount of D2 neurons
-normal DA levels -leads to overactivity of thalamic neurons which overly stimulate motor cortex |
