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17 Cards in this Set
- Front
- Back
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Clostridium tetani
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Tetanospasmin (neurotoxin)
H subunit: binds neuronal gangliosides L subunit: blocks release of inhibitory neurotransmitters |
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Clostridium botulinum
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Botulinum toxin (neurotoxin)
Inhibits acetylcholine release at NMJ |
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Vibrio cholerae
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Choleragen (enterotoxin)
A-5B: ADP ribosylation of G protein stimulates adenylate cyclase, increasing cAMP in gut (induces NaCl secretion, inhibits NaCl reabsorption) |
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Escherichia coli (ETEC)
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Heat labile toxin (enterotoxin)
A-5B: ADP ribosylation of G protein stimulates adenylate cyclase, increasing cAMP in gut (induces NaCl secretion, inhibits NaCl resorption) Heat stable toxin (enterotoxin) Activates guanylate cyclase to produce GMP (inhibits NaCl resorption) |
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Campylobacter jejuni
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Enterotoxin
A-5B: ADP ribosylation of G protein stimulates adenylate cyclase, increasing cAMP in gut (induces NaCl secretion, inhibits NaCl resorption) Cytotoxin Destroys mucosal cells |
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Bacillus cereus
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Heat labile toxin (enterotoxin)
A-5B: ADP ribosylation of G protein stimulates adenylate cyclase, increasing cAMP in gut (induces NaCl secretion, inhibits NaCl resorption) |
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Yersinia enterocolitica
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Heat stable toxin (enterotoxin)
Activates guanylate cyclase to produce GMP (inhibits NaCl resorption) |
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Shigella dysenteriae
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Shiga toxin (enterotoxin)
A-5B: Inhibits protein synthesis of intestinal epithelial cells by inactivating 60s ribosomal subunit |
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Escherichia coli (EHEC and EIEC)
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Shiga-like toxin (enterotoxin)
A-5B: Inhibits protein synthesis of intestinal epithelial cells by inactivating 60s ribosomal subunit |
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Staphylococcus aureus
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Staphylococcal heat stable toxin (enterotoxin)
Toxic shock syndrome toxin 1 (TSST-1) (pyrogenic toxin) Superantigen: Activates the endogenous mediators of sepsis Tissue invasive toxins Lipases, Penicillinase, Staphylokinase, Leukocidin, Exfoliatin, complement binding factors |
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Streptococcus pyogenes (Group A)
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Streptococcus pyrogenic toxin
Superantigen: Activates the endogenous mediators of sepsis Tissue invasive toxins Hemolysins/Streptolysin: Lyses red blood cells Streptokinase: Activates plasminogen DNAse, NADase, Hyaluronidase |
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Clostridium perfringens
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Alpha toxin (tissue invasive toxin)
Lecithinase hydrolyses lecithin in cell membranes (cell death) |
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Bacillus anthracis
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Anthrax toxin
1. Protective antigen: binding 2. Edema factor: calmodulin-dependent adenylate cyclase increases cAMP 3. Lethal factor: zinc metalloprotease that inactivates protein kinase, causes TNF and IL1 release |
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Corynebacterium diphtheriae
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Diphtheria toxin
A/B: ADP ribosylation of elongation factor 2 leads to inhibition of protein synthesis |
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Bordetella pertussis
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Pertussis toxin
A/B: activates G proteins, adenylate cyclase increases cAMP Extracytoplasmic adenylate cyclase (Similar to edema factor) impairs chemotaxis and phagocytosis Filamentous hemagglutinin Binds to ciliated epithelial cells Tracheal cytotoxin Damages respiratory epithelial cells |
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Clostridium difficile
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A/B: causes fluid secretion and mucosal inflammation, leading to diarrhea
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Pseudomonas aeruginosa
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Pseudomonas exotoxin A
A/B: ADP ribosylation of elongation factor 2 leads to inhibition of protein synthesis |
