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12 Cards in this Set
- Front
- Back
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different kind of antibiotics? |
beta-lactams (block cell wall synthesis) Methicillin (binds to BPBs) Vancomycin (ala-D-ala to ala-D-lac) Erythromycon, chloramphenicol (inh 50S) Tetracycline, Kanamycin (inh 30S) Sulfonamides, Trimethoprim (folic acid) Fluropquinolones (supercoil) Rifampicin (inh RNA polymerase) Polymyxin B (lind LPS in Gram Negative Ba) |
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Bacterial strategies for antibiotic resistance |
Preventing of antibiotic entry antobiotic modification (beta-lactamase) Efflux of antibiotic (pump out antibiotic) Alteration of antibiotic target (PBPs, ribosome modifications) Bypassing the antibiotic action (use environmental folic acid) |
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Bacterial transformation |
Release for DNA |
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Bacterial transduction |
phage |
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Bacterial conjugation |
conjugere and transform |
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•Enterococcusfaecium (VRE) |
Gram positive intestinal tract in mammals resistance due to the van genes |
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•Staphylococcus aureus (MRSA) |
gram negative
virulence factors as pili, LPS and biofilm formation |
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•Klebsiella species |
Gram negative
produce a capsule and is commonly resistant to multiple antibiotics |
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•Acinetobacter baumannii |
d |
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•Pseudomonas aeruginosa |
d |
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•Enterobacterand E. coli |
d |
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Clostridia |
Gram positive rod shape endospore-formers strict anaerobes, killed by O2 can cause life threatening diesease mediated by exotoxins cause the disease pseudemembranous colitis - inflammatory condition of the large intestine, smalling diarrhea |
