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10 Cards in this Set

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This gram-negative diplococci organism is a common colonizer of the oropharynx and is spread by respiratory route, especially among young individuals (5-19 yrs. old)?
Neisseria meningitidis
How does Neisseria meningitidis get into the blood stream?
The bacteria must invade respiratory epithelial cells and travel to the basolateral side of the cells to enter the blood steam.
Untreated Neisseria gonorrhoeae infections in women can lead to?
PID, which can cause infetility or ectopic pregnancy
Disseminated Neisseria gonorrhea infections of adults and adolescents usually cause?
septic arthritis accompanied by a rash of hemorrhagic papules and pustules
Neonatal N. gonorrhea infection causes?
blindness and (rarely) sepsis
What complement-regulatory protein expressed by all human nucleated cells does the long pili of N. gonorrhea bind to?
CD46
How does Neisseria gonorrhea form new pili proteins so that the immune system cannot respond?
homologous recombination b/t silent loci and the expression loci
Where are OPA proteins located?
The outer membrane of Neisseria
What do OPA proteins do?
They increase binding of Neisseria to epithelial cells and promote entry of bacteria into cells.
How are different amounts and new OPA proteins expressed?
5-nucleotide sequence is frequently deleted or duplicated shifting the reading frame of the gene to form new sequences and stop codons can be formed which determines whether the OPA gene is expressed or not.