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5 Cards in this Set

  • Front
  • Back
4 bacteria that produce IgA proteases.
1. Neisseria meningitides
2. Streptococcus pneumoniae
3. Haemophilis influenzae
4. Neisseria gonorrhoeae
Describe how LPS exerts an effect.
Acts on macrophages.
They release TNFalpha/other cytokines.
These act on other cells causing release of PAF, kinins, leukotrienes, ROI, proteases, NO.
Leading to host defense and shock.
Describe role of toll receptors.
LPS interacts with TLR-4 which send signal to cell.
TLR-2 is assoc c other PAMPS.
Gram neg: Think TLR-4
Gram pos: Think TLR-2.
Describe 3 types of exotoxins.
1. Type 1 (superantigen:bind to surface.
2. Type 2. Phospholipases which make pore in cell membrane.
3. Type 3. ADP-ribosyl transferaes & zinc proteases. Have active and binding components; act against intracellular proein target.
3 most common causes of bacterial meningitis.
1. neisseria meningitidis
2. hemophilus influenzae
3. strptococus pneumoniae.