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12 Cards in this Set
- Front
- Back
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What is the pathogenesis of Corynebacterium renale?
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organisms normally in habit in the lower genital tract of ruminants and other animals
causes pizzle rot in sheep and pyelonephritis in cattle Pili attach to urothelium Urease breaks down urea into ammonia causes inflammatory process high alkalinity of urine and suppression of antibacterial defenses ammonia inactivates complement |
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What is the pathogenesis of Rhodococcus?
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affects young foals causes pneumonia
bacteria found in soil and manure ingestion followed by opsonization by C3b by macrophages bacteria escapes or survives inside the phagolysosome (Vaps, cell wall) down regulates IFN-y sub-acute to chronic inflammatory response can get Vaps antibody from passive immunity |
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What is the pathogenesis of Arcanobacteria?
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causes suppurative process of swine and ruminants more infections are endogenous
causes summer mastitis and abortion Physical or microbial damage adhesion (binds to collagen and fibronectin) neuroaminidases aid in binding and exposure of receptors Proteases aid in the spread of the organism |
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What is the pathogenesis of Listeria?
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affects human other species of animals especially ruminants
causes septicemia, encephalitis and abortion found in soil, water and poor silage via oral route: bacteria that survive gastric acid attach enter and survive in epithelial cells, M cells and phagocytic cells and disseminate in the blood stream via injury: bacteria travel peripheral nerves and cause CNS signs |
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What is the pathogenesis of Erysipelothrix?
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affects swine between than 3 mons and over 3 years
affects male turkey and sheep due to fighting Bacterial attachment and invasion into cells by neuraminidase vascular damage and hyaline thrombus formation resistance to phagocytosis (capsule) causing septicemia and diamond skin disease in pigs |
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What is the pathogenesis of Mycobacterium?
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saprophytic organism that causes tuberculosis, leprosy and granulomatous disease
source of tibercle bacilli is from specific individuals tuberculosis (humans) bovis (white tail dear) avium (chickens) bacteria are taken up by the macrophates and are activated activated macrophages secrete IL-12 IL12 induces production of INF-y and attracts macrophates monocyte migration inhibition factor holds monocytes in infections focus activated macs kill mycobaterium also targeted by CD8 TH1 cells |
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What is the pathogenesis of actinomyces
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a filamentous bacteria that causes lumpy jaw in bovine and found on tooth surfaces and mucous membranes
bacteria introduced by a traumatic event chronic event causes osteomyelitis bone is replaced with porous bone, dislodgement of teeth, inability to chew and mandibular fractures |
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What is the pathogenesis of Nocardia?
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filamentous bacteria that causes suppurative pyogranulomatous in immunosupressed animals, causes bovine mastitis
saprophytes in soil and water and transmitted by inhalation ingestion or trauma protection from phagocytic killing (superoxide dismutase) high in mycolic acid and lipids see sulfur granules |
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What is the pathogenesis of Dermatophilus?
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filamentous bacteria that causes supperative dermatitis and increase economic lose for animal hides
transmitted by arthropod vector or contact with infected can be self limiting |
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What is the pathogenesis of non-sporing obligate anaerobes?
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can be gram neg or pos and some are part of normal flora
inoculation of anaerobes in compromised site, decrease O2 in tissues causes continuous inflammatory responses due to capsule cell wall toxins and phagocytosis |
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What is the pathogenesis of invasive clostridium?
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found in soil
causes enterotoxemias causes gas gangrene and yellow lamb disease (perfringes) diarrhea in humans resistant spores (difficile) big head and black disease of fighting sheep (novyi) hemolytic crisis of ruminants, in kuffer cells due to flukes (haemolyticum) causes malignant edema and gas gangrene (septicum) causes black leg necrotizing myolitis (chauvoei) tramatic event, bacteria spread by which ever way they enter and causes disease based on species |
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What is the pathogenesis of non invasive bacteria?
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produce disease strictly through the action of neurotoxins (found in soil)
causing flaccid paralysis, blocks Ach by BoNT (botulinum) causes tonic-clonic conculsions by inoculation of a traumatic wound by tetanolysin and tetenospasmin (tetani) both are zinc endopeptidase that bind to cholinergic nerve cells |
