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24 Cards in this Set
- Front
- Back
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5 gram neg bacilli
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1. E. coli (entero)
2. V. cholerae (vibrio) 3. Salmonella (entero) 4. aeruginosa (pseudo) 5. Haemophiluls influenzae |
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3 gram neg bacilli enteric families
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1. enterobacteriaceae
-escherichia, salmonella, e coli, klebsielia, proteus -fac anaer 2. vibrionaceae -cholerae -fac anaer 3. pseudomomadaceae -aeruginosa -oblig aerobe |
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enterics:
2 lactose fermenters 1 non-lactose |
1. E. coli
2. Klebsielia 1. Proteus |
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entero:
3 antigens |
H: flagella
O: polysac part of LPS K: capsule |
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e coli diseases and virulence factors
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1. UTI: adhesins (pili, fimbriae, intimin)
2. neonatal meningitis: K-1 Ag 3. gastroenteritis: toxins, adhesins, invasive factors 4. bacteremia: K Ag |
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e coli toxins
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1. toxigenic: heat stable, stim fluid hypersecr
2. invasive: epith in colon 3. pathogenic: epith in gut 4. aggregative: to epith, prevents fluid absorption 5. hemorrhagic: lysogenic, Shigalike toxin |
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e coli treatment
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1. UTI
fluoroquinolones 2. neonatal mening: cephalosporin 3. gastroenteritis: fluid/electrolyte 4. bactermia: cephalosporin |
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def:
1. bacteremia 2. sepsis/septicemia 3. septic shock 4. toxic shock |
1. bac in blood
2. w/symp 3. bac w/TNF-alpha 4. toxins not bac in blood |
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salmonella dis
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1. enteritis
2. bacteremia 3. typhoid fever |
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salmonella virulence
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1. adherence and invasion factors
2. surv phag 3. acid tol |
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3 ways to surv phag
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1. inhib phag-lys fusion
-tuberculosis, chlamdia 2. escape from phag -Shigella, Listeria 3. repl in phag-lys -salmonella |
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human reservoir
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1-5% non-sympt carriers
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salmonella typhoid treatment
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1. fluoroquinolones
2. cephalosporin 3. chloramphenicol |
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vibrio cholerae virulence
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1. cholera toxin
-fluid hypersecr due to up cAMP 2. adhesion factors 3. siderophores (iron sequestration) |
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vibrio cholerae treatment
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1. adult tetracyclin
2. kids: TMP-SMX 3. pregnant: furazolidone |
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pseudomonas aeruginosa:
nosicomial dis |
1. pulm infect
2. UTI 3. bacteremia, endocarditis 4. skin: burns, surg sites |
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pseudomonas aeruginosa:
comm dis |
1. cystic fibrosis: pulm
2. ear infect 3. skin and soft tissue: wound, folliculitis |
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aeruginosa virulence
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1. adhesion: pili, neurminidase
2. flag 3. endotoxin A: disrupts transl 4. pyocyanin pigment: tissue damage 5. enzyme: -exoenzyme S, -elastase, -phospholipase C (hemolysin) 6. biofilm: lung |
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aeruginosa treatment
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1. piperacillin AND
2. an aminoglycoside or quinolone |
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non-enteric gram neg bacilli
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haemophilus influenzae
-fac anaerobe -mouth |
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haemophilus influenzae dis:
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meningitis, conjunctivitis, otitis media, epiglottis, pneumonia
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haemophilus influenaze virulence
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polysac capsule, serotype a-f, b worst
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H. influenzae diag: 2 growth factors
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1. x factor: protoporphyrin 9 (precursor of hemin)
2. V factor: NAD, NADP |
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H. influenza treatment/prev
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1. cephalosporins
2. conjugated vaccine: makes Ag T-cell dependent |
