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14 Cards in this Set
- Front
- Back
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Name a process that requires folate?
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Purine synthesis (conversion of dUMP to dTMP)
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Injested folate needs to be activated by?
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Dihydrofolate reductase (DHFR)
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What vitamin is required for DNA synthesis and cell division?
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Folate
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The most stable form of folate is?
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N5-methyl-FH4
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How is N5-methyl-FH4 recycled?
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donating a methyl to B12
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What does B12 bind to after injestion?
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Intrinsic factor
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The conversion of methylmalonyl-CoA to Succinyl CoA requires?
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Vitamin B12
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What is required for the transfer of methyl group from N5-methyl-FH4 to homocysteine to form methionine?
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Vitamin B12
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What molecule will build up if you don’t have enough Adenosyl B12?
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methylmalonic acid
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You need folate to make?
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methyl-B12
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Homocysteine accumulates if you don’t have enough?
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methyl-B12
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What test do you order to determine if a patient has an intrinsic factor issue related to B12?
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Schilling test
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A problem with intrinsic factor deficiency would indicated?
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pernicious anemia
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SAM is required for DNA and histone ___.
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Methylation
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