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15 Cards in this Set
- Front
- Back
What do Macrophages release?
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Cytokines: IL-1, TNF-alpha, IL-6, CXCL-8
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What does IL-1 produce?
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IL-6
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What does IL-1 and TNF-alpha do aside from causing FEVER?
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activate Vascular epithelium (access to effector cells), tissue destruction
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What does IL-1 and IL-6 do?
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activate LYMPHOCYTES and increase production of liver proteins (fibrinogen, *Mannos Lectin, *C-ractive Protein) *opsonization
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What does IL-12 tell us about the infection?
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that its bad! at this point IL-12 activate NK cells and TH-1 cells
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What Cytokine released from the spleen and liver because of gran-negative bacteria cause SEPSIS?
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TNF
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Anti-TNF (Enbrel) drug that targets TNF Receptor 1 is targeted at what disease?
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Rheumatoid Arthritis
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What is the side effect of Anti-TNF (Enbrel) therapy?
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suseptability to TB and Lymphoma
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What effect does Enbrel have on Multiple Sclerosis Patients?
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It makes it worse because Enbrel blocks production of myelin in the brain via TNF receptor 2
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What activtes endothelial eNOS?
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Ca++
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What causes macrophage iNOS activation?
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TNF
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eNOS and iNOS make NO, what does NO activate?
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smooth muscle relaxation and vasodilation
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eNOS and iNOS make NO, what does NO inhibit?
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inflamation (mast cells, Leukocyte recruitment), adhesion of leukocytes and platelets to b.v.
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What does cytokine CXCL-8 bring to the site of infection?
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Basophils, NEUTROPHILS, T cells
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What does CC bring to the site of infection?
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eosinophils
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