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7 Cards in this Set
- Front
- Back
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) Small/medium blasts; scant
cytoplasm; indistinct nuleoli CD10, CD19, TdT with aberrant expression of CD13 and CD33 Worst prognosis of all ALL |
w/t(9;22)(q34;q11.2)
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d Small/medium blasts; scant
cytoplasm; indistinct nuleoli. May be able to recognize monoblastic component in blood or bone marrow CD19, CD15 positive; CD10, CD14 negative Poor, especially in patients <6mo. |
w/t(v11q23);MLL rearranged
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Small/medium blasts; scant
cytoplasm; indistinct nuleoli CD10, CD19 Positive; Most CD34 positive; Lack CD20; Often express CD13 |
w/t(12;21
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Small/medium blasts; scant
cytoplasm; indistinct nuleoli CD10, CD19 Positive; Often CD34+, CD45dim or absent Numerical increases in chromosomes, usually without structural abnormalities. Usually Ch 21, X, 14 and 4 copy number changes |
w/hyperdiploidy
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Small/medium blasts; scant
cytoplasm; indistinct nuleoli Loss of one or more chromosome. Structural abnormalities may be seen in other chromosomes. Hypodiploid may be detected by flow cytometry. Poor prognosis, worse with greater loss of material CD10, CD19 |
w/hypodiploidy
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) Small/medium blasts; scant
cytoplasm; indistinct nuleoli. Associated with an increase in circulating eosinophils. This is a reactive change and not part of the neoplastic process CD10, CD19 --Uncertain ) Functional rearrangement of the IL3 gene on Chromosome 5 with IGH gene on 14. Constitutive expression of IL3 |
w/t(5;14)
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Medium uniform blasts with
high proliferative rate. Does not occur in peripheral blood, even with bone marrow involvment --- TdT negative CD10, CD19, CD20, CD22; Aggressive but curable, especially early in disease. |
w/t(1;19)
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