Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
32 Cards in this Set
- Front
- Back
|
Cardioselective beta blockers (B1)and pneumonic
|
AABBMEN
acebutolol atenolol betaxolol bispropolol esmolol metoprolol nebivolol |
|
|
Nonselective beta blockers (B1 and B2) and pneumonic
|
PPTN (precipitation) is bad
propanolol pindolol timolol nadolol |
|
|
Nonselective antagonists(B1+B2+ alpha 1)
|
Carvedilol
Labetolol |
|
|
B-blockers with ISA activity
|
I SAid Pin the Ace on the Label
ISA: pindolol acebutolol labetolol |
|
|
B-blockers with MSA activity
|
MJ SAid Pin the Ace on the Label Properly Becuz
MSA: pindolol acebutolol labetolol propanolol betaxolol |
|
|
B-blockers used for migraine propylaxis
|
Propanolol
Timolol |
|
|
B-blockers that show a CHF survival benefit
|
I Met two (Bis)Carvers, who saved me from CHF
Bispropolol Metopropolol Carvedilol |
|
|
B2 antagonist effects
|
Bronchoconstriction
Peripheral vasoconstriction slowing of glycogen metab lower blood glucose |
|
|
B2 antagonists should not be used or used cautiously with which disease states?
|
COPD (broncoconstriction)
Asthma Diabetes (glucose pathways) |
|
|
B1 and B2 antagonist side effects
|
Bronchoconstriction
Hypoglycemia Bradycardia CNS effects (depression) Cold extremities Arrhythmias (upregulation of R's with use) |
|
|
Propanolol properties
|
B1 and B2 antagonist
MSA Lipophilic (CNS effects) 1st line migraine propylaxis Anxiety Cyp2D6 metabolism Lots of 1st pass metabolism |
|
|
First line migraine propylaxis drug
|
Propanolol
|
|
|
Nadolol properties
|
Very long half life (14-24h)
hydrophilic Fewer CNS effects than Propanolol ! Prop is lipophilic no MSA or ISA |
|
|
Timolol properties
|
2nd line drug for migraine Px Opthalmic gel or oral
Open angle glaucoma Tx Can be absorbed systemically as an eye gel |
|
|
Structural feature of B1 selective (cardioselective) antagonists
|
para substitution increases B1 selectivity
|
|
|
Dosing feature of cardioselective (B1) antagonists
|
Selective for B1 at lower doses.
Less selective at high doses |
|
|
Atenolol properties
|
B1 selective
Hydrophilic (low CNS effects) Not metabolized Excreted unchanged HTN, Angina, Post MI |
|
|
Atenolol indications
|
HTN
Angina Post MI |
|
|
Propanolol indications
|
HTN
Anxiety Migraine prophylaxis |
|
|
Betaxolol properties
|
B1 specific
MSA HTN and Glaucoma No B2 so OK for asthma |
|
|
Betaxolol indications and uses with disease states
|
HTN
Glaucoma OK for asthma patients since no B2 antagonism |
|
|
Esmolol properties
|
IV administration
Very short (10 min) half life Superventricular Tachycardia TX Rapid acting Emergency use |
|
|
Metoprolol properties
|
CHF survival benefit
CYP2D6 metabolism |
|
|
Nebivolol unique effect
|
Elicits vasodialation of coronary blood vessels via activation of endothelial B3 R's
"nitrous oxide" pathways |
|
|
B antagonists that provide a CHF survival benefit
|
Metoprolol
Bispropolol Carvedilol |
|
|
Nebivolol properties
|
Most B1 selective antagonist
Elicits vasodialation of coronary blood vessels |
|
|
Alpha 1 antagonist side effect
|
orthostatic hypotension
|
|
|
Labetalol properties
|
B1+B2+alpha 1 antagonist
MSA ISA IV use in hypertensive emergencies |
|
|
Carvedilol properties
|
B1+B2+alpha 1 antagonist
Antioxidant effects CHF survivial benefit Lipophilic (CNS effects) |
|
|
B blockers with greatest CNS effects
|
Propanolol Metoprolol
Pindolol Carvedilol "Cant Make Proper Plans" on CNS drugs |
|
|
B blocker for hypertensive emergencies
|
Labetalol
|
|
|
Metoprolol dosages
|
Succinate (Toprol XL) has once daily dosing
Tartrate (Lopressor) has twice daily dose |
