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91 Cards in this Set
- Front
- Back
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Name the DNA viruses
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Poxvirus
Herpesvirus Adenovirus Papovavirus Parvovirus |
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Name the RNA viruses
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Paramyxovirus
Orthomyxovirus Rhabdovirus Reovirus Togavirus Picornavirus (includes enterovirus) |
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Viral dz that is assoc with cephaolcaudal spread of rash?
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Measles (rubeola)
Rubella |
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Red cheeks, reticulate lacy rash?
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Parvovirus (B19)
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Rash starts when fever subsides?
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Exanthem subitum (HHV6 or HHV7)
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Abx associated exanthem (ex., with amoxicillin) seen with what virus?
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CMV, EBV
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Koplik spots?
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Measles
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Forschheimer's spots?
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Rubella
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Nagayama's spots?
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HHV6 or HHV7
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Postauricular LAD?
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Rubella
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What viral illnesses can have assoc hepatosplenomegaly?
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Measles
EBV CMV |
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What viral illnesses can have assoc PNA?
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Measles, Adenovirus, Enterovirus
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What viral illnesses can have assoc myocarditis?
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measles
rubella enterovirus |
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What is the most common cause of hand-foot-and-mouth-disease?
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enterovirus (coxsackievirus A16)
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What is herpangina?
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febrile illness of children ages 3-10 yrs with painful vesicles and erosions on the soft palate, uvula, tonsils, pharynx and buccal mucosa
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What type of virus causes Measles?
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paramyxovirus
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What virus causes rubella?
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RNA virus, Togaviridae family
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What virus can cause papular-purpuric gloves and socks syndrome?
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Parvovirus B19
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What is the cause of Unilateral laterothoracic exanthem?
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Unknown
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Eponym for Papular acrodermtitis of childhood?
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Gianotti-Crosti
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MC assoc viruses with Gianotti-Crosti?
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Hep B virus
EBV |
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MC poxvirus infection in humans?
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Molluscum contagiosum
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Name of the large, intracytoplasmic inclusion bodies found in molluscum?
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Henderson-Patterson bodies
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kawasaki's is aka?
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mucocutaneous LN synddrome
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What mosquito transmits West Nile Virus?
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Culex mosquitos
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What virus causes chikungunya fever?
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chikungunya virus -- member of Togaviridae vamily
Transmitted by Aedes aegypti and A. Albopictus |
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What type of virus causes rabies?
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neurotropic RNA virus in the genus Lyssavirus
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What are the three major groups of HHVs? Name examples of each.
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Alphaherpesviridae (HSV1, HSV2, VZV)
Betaherpesviridae (CMV, HHV6, HHV7) Gammaherpesveridae (HHV8) |
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HHV1
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HSV1
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HHV2
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HSV2
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HHV3
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VZV
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HHV4
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EBV (Epstein Barr)
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HHV5
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CMV
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HHV6
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HHV6 - Roseola infantum, aka Exanthem subitum, Sixth Dz
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HHV7
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HHV7 - assoc with HHV6 (exanthem subitum)
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HHV8
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Kaposi's Sarcoma-assciated herpes virus
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Eczema herpeticum aka?
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Kaposi's varicelliform eruption (disseminated HSV eruption)
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HSV infection of the digits?
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Herpetic whitlow
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Direct contact infection, usually in athletes?
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Herpes gladiotorum
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What is the 2nd MC cause of corneal blindness in US?
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Ocular HSV
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What is the MC cause of sporadic, fatal viral encephalitis in US?
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HSV
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HSV encephalitis affects what lobe and what is the mortality rate?
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temporal lobe is affected and mortality is appx 70%
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Prevalence and risk factors for neonatal herpes?
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1 in 2000-5000 deliveries. highest risk is in first episode HSV near time of delivery (33-50%) vs <3% in women with recurrent herpes
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What drug is approved for acyclovir resistant HSV?
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foscarnet
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Can you get chickenpox from someone with zoster?
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Yes!!
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What are some complications of VZV infection?
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CNS complications, Reye's syndrome, encephalitis, and acute cerebellar ataxia, PNA, optic neuritis, keratitis, arthritis, myocarditis, pancreatitis, orchitis, hepatitis, vasculitis
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What is Ramsey-Hunt syndrome?
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Reactivation of VZV in the geniculate ganglion: vesicles in ear canal, tongue, hard palate, facial nerve palsy, pain in the ear, loss of taste of the anterior 2/3s of the tongue, dry mouth and eyes. Can also get tinnitus, hearing loss, vertigo.
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What are the most common EBV-associated Dz in the US?
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Infectious Mononucleosis
B-cell lymphoas (~20%) lymphoproliferative disorders (worldwide can have mono, african-endemic Burkitt's lymphoma and nasopharyngeal carcinoma) |
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What protein is important in helping to establish EBV latency and evasion?
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EBNA-1 protein and viral LMP-2 gene (EBV binds to cell surface complement receptors CR2 or CD21)
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Viral Capsid Antigin (VCA) IgG positive, VCA IgM positive, EBNA IgG negative --
Acute or Chronic EBV? |
Acute primary infection
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Viral Capsid Antigin (VCA) IgG positive, VCA IgM negative, EBNA IgG positive --
Acute or Chronic EBV? |
Past persistent infection
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What virus has been assoc with Kikuchi's syndrome?
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EBV (HHV4)
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What is the leading infectious cause of congenital deafness and mental retardation?
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CMV (HHV5) -- TORCH syndrome
In US, 0.5-1.5% of all newborn infants |
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What is the MC cause of blindness in HIV patients?
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CMV
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What agent causes blueberry muffin baby? What causes the spots?
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papules and nodules are dermal erthropoesis -- CMV can cause this
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What cells are targets of HHV 6?
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Roseola infantum -- tropism for CD4+ lymphocytes
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What are Nagayama's spots
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enanthem of red papules on the soft palate seen in roseola infantum (exanthem subitum)
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What are the four types of KS?
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Classic (peaks in 6th decade, Ashkenazi jews)
HIV/AIDs related Immunosuppression associated African endemic |
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Name the four types of African endemic KS?
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Nodular
Lymphadenopathic Florid Infiltrative |
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What immunohistochemical stain can detect HHV?
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LNA-1 (Latent Nuclear Antigen)
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What type of virus is HPV?
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DNA virus, Family Papova
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Which HPV virus causes common warts?
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2,4
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Which HPV virus causes laryngeal papillomas?
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6,11
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Which HPV virus causes laryngeal carcinoma?
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30
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Which HPV virus causes Buschke Loewenstein Tumor?
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6,11
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Which HPV virus causes Bowenoid papulosis?
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16
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Which HPV virus causes Butcher's?
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7
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Which HPV virus causes Epidermodysplasia verruciformis?
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5,8
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Which HPV virus causes SCC and genital tumors?
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16,18
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Which HPV virus causes Heck's (FEH)?
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13,32
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Which HPV virus causes flat wart?
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3,10
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Which HPV virus causes palmoplantar?
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1,2,4
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What type of virus is causes Molluscum contagiosum?
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double stranded DNA, poxvirus;
MCV 1 to 4, MCV 1 is the most common |
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Which HPV virus causes periungual tumors?
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16
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Which HPV virus is linked to Verrucous Carcinomas?
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6,11
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Is HPV a DNA or RNA virus?
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DNA
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Eczema Herpeticum aka?
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Kaposi' varicelliform eruption;
viremia is possible so treat with IV acylovir |
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What type of HHV is VZV?
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HHV 3
Infective from 2 days b/f fever to crusting of lesions |
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What type of HHV is Epstein Barr?
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HHV 4
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What type of HHV is CMV?
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HHV 5
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What type of HHV is Roseola?
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HHV 6, 7
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What type of HHV is Kaposi's?
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HHV 8
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What is the VZV pregnancy window?
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Risk of transmitting VZV if you get chickenpox 5 days before and 2 days after delivery.
Rx baby with IVIG |
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Can you get chickenpox from a zoster patient?
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Yes
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Can you get zoster from a zoster pt?
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No
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Can you get zoster from the vaccine?
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Yes
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Can you get zoster from a chickenpox patient?
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No
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Does zoster affect the fetus?
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No
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What is Ramsey Hunt syndrome?
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HSV of the geniculate ganglion -- less likely to recover from bell's palsy if this is the cause.
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What is a complication of sacral zoster?
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neurogenic bladder
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Which HPV Virus is commonly associated with genital warts?
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6, 11, 16
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