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25 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Hemicholinium
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Blocks choline uptake
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Presynaptic only gets hemi-choline
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Vesamichol
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Prevents vesicular filling with ACh
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Vesicles+choline
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Metyrosine
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Inhibits Tyrosine Hydroxylase (Tyrosine-->DOPA)
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Reserpine
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Inhibits VMAT. No Dopamine, Norepiniephrine, Serotonin in vesicles (all degraded by MAO).
AE: Depression, Nasal Congestion, peptic ulcer, diarrhea. |
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Guanethidine
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Inhibits release of catecholamines
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Bethanechol
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Cholinergic Agonist. Used for ileus and neurogenic retention (activates Bowel and Bladder). Resistant to ACh-Estrase.
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B+Choline
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Carbachol
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Cholinergic Agonist. Glaucoma, pupillary constriction, release intraocular pressure.
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Choline
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Pilocarpine
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Cholinergic Agonist. Stimulates sweat, tears saliva. Resistant to Ach-Estrase. Opens canal of Schlemm, used for glaucoma emergencies.
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Contracts ciliary muscle and pupillary sphincter.
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Methacholine
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Cholinergic Agonist. Asthma challenge test (airway muscarinic receptors).
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Muscarinic+Choline
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Neostigmine
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ACh-E inhibitor (indirect cholinergic agonist). Ileus, urinary retention, Myasthenia, reverse neuromuscular blockade. NO CNS penetreation
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Pyridostigmine
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ACh-E inhibitor (indirect cholinergic agonist). Myasthenia (long acting). NO CNS penetration
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Edrophonium
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ACh-E inhibitor (indirect cholinergic agonist). Diagnose Myasthenia (very short acting).
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Tensilon test
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Physostigmine
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ACh-E inhibitor (indirect cholinergic agonist). Glaucoma, atropine overdose. Crosses BBB, CNS penetration.
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PHYS for the EYES
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Echothiophate
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ACh-E inhibitor (indirect cholinergic agonist). Glaucoma.
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Pralidoxime
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Regenerates active cholinesterase. Used to treat ACh-E Inhibitor poisoning.
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Benztropine
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CNS Muscarinic Antagonist. Used for Parkinson's.
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Scopolamine
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CNS Muscarinic Antagonist. Used for motion sickness.
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Methscopolamine, oxybutynin, glycopyrrolate
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Genitourinary Muscarinic Antagonist. Reduce urgency in cystitis, reduces bladder spasms.
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Pirenzepine, propantheline
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GI Muscarinic Antagonist. Peptic ulcer treatment.
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Glaucoma Drug Categories
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Alpha Agonists (decrease aqueous humor synthesis).
Beta Blockers. Diuretics (Acetazolamid, decreased secretion from decreased bicarbonate). Cholinomimetics. Prostaglandin (Increase outflow) |
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Hexamethonium
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Nicotinic Antagonist. Glanglionic blocker. Used to prevent vagal response to changes in blood pressure.
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Terbutaline, Ritodrine
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Beta-2 Agonists. Reduce premature uterine contractions.
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Mirtazapine
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Alpha-2 blocker. Treat depression.
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P450 Inducers
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Quinidine, Barbituates, Phenytoin, Rifampin, Griseolfulvin, Carbamazapine, St. John's wort.
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Queen Barb take Phen-phen and Refuses GReasy CARB Shakes.
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P450 Inhibitors
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Isoniazid, Sulfonamides, Cimetidine, Ketoconazole, Ertythromyic, Grapefruit juice (3A4).
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Inhibitors Stop Cyber-Kids from Eating Grapefruit.
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