Autonomic Pharmacology Receptors

Front 1

Eye pupillary response Sympathetic

Back 1

contracts radial muscle -> dilation mydriasis

alpha 1

Front 2

Eye pupillary response parasympathetic

Back 2

contracts circular/sphincter muscle constriction (miosis)

M3

Front 3

Eye lenticular response (accommodation) parasympathetic

Back 3

Contracts ciliary muscle -> near vision

M3

Front 4

Eye lenticular response (accommodation) sympathetic

Back 4

relaxes ciliary muscle -> far vision

Beta 2

Front 5

Aqueous Humor Sympathetic

Back 5

Increased secretion of aq humor from ciliary epithelium -> inc IOP
Beta 2

decreased production of aqueous humor (presynaptic inhibition) lowers IOP
alpha 2

Increased outflow of aq. humor lowers IOP
alpha and beta

Front 6

Aqueous Humor Parasympathetic

Back 6

contraction of ciliary muscle inc the pressure of trabecular meshwork, opening pores inc outflow of aq humor into canal of schlemm-> lowers IOP
M3

Front 7

SA node symp

Back 7

accelerates heart rate
B1

Front 8

SA node (pacemaker) parasymp

Back 8

dec heart rate
M2

Front 9

Atria Symp

Back 9

increases contractility and conduction velocity
B1

Front 10

Atria Parasymp

Back 10

decreases contractility and shortened Action potential duration
M2

Front 11

AV node symp

Back 11

increases automaticity and conduction velocity
B1

Front 12

AV node parasymp

Back 12

decreases conduction velocity; AV block
M2

Front 13

Ectopic pacemakers (can cause irregular beats) Symp

Back 13

accelerates heart rate
B1

Front 14

Ectopic pacemakers Parasymp

Back 14

no effect

Front 15

heart: Contractility Symp

Back 15

Increases force of contraction
B1

Front 16

heart: Contractility Parasymp

Back 16

decreases in atria only
M2

Front 17

Blood vessels: skin and splachnic vessels Symp

Back 17

contracts
a1

Front 18

Blood vessels: skin and splachnic vessels parasymp

Back 18

no effect

Front 19

Blood vessels: skeletal muscle vessels Symp

Back 19

relaxes B2
contracts (inc BP) alpha 1
some sympathetic cholinergic fibers lead to dilation (dec BP) M(?)

Front 20

Blood vessels: skeletal muscle vessels Parasymp

Back 20

no effect

Front 21

Blood vessels: endothelium sympathetic

Back 21

no effect

Front 22

Blood vessels: endothelium parasympathetic

Back 22

relaxes, vasodilation
M3

(release of NO-> guanylyl cyclase-> cGMP-> inhibiting Ca+2 release from SR -> prevents muscle contraction : can only be caused by circulating cholinergic agonists

Front 23

Lung: Bronchial and Tracheal smooth muscle Symp

Back 23

relaxes, bronchodilation
B2

Front 24

Lung: Bronchial and Tracheal smooth muscle parasymp

Back 24

contraction, bronchoconstriction
M3

Front 25

Lung: bronchial glands symp

Back 25

dec secretion a1
inc secretion b2

Front 26

Lung: bronchial glands parasymp

Back 26

stimulation
M3, M2

Front 27

GI tract: Smooth muscle walls Symp

Back 27

relaxation; might be due to presynaptic inhibition of ACh release in parasymp terminals
a2, B2

Front 28

GI tract: Smooth muscle walls Parasymp

Back 28

contraction- inc peristalsis
M3

Front 29

GI: Smooth muscle sphincters
sympathetic

Back 29

contraction
a1

Front 30

GI: Smooth muscle sphincters
parasymp

Back 30

relaxation
m3

Front 31

GI: Secretion Symp

Back 31

inhibition
a2

Front 32

GI: secretion Parasymp

Back 32

increases secretions
M3

Front 33

GI: Myenteric plexus symp

Back 33

no effect

Front 34

GI: Myenteric plexus parasymp

Back 34

Potentiates activity resulting in further increases in smooth muscle tone and contractility
M1

Front 35

Genitourinary smooth muscle: Bladder wall symp

Back 35

relax
B2

Front 36

Genitourinary smooth muscle: Bladder wall parasymp

Back 36

contract
M3

Front 37

Genitourinary smooth muscle: Sphincter sympathetic

Back 37

contract
a1

Front 38

Genitourinary smooth muscle: Sphincter parasympathetic

Back 38

relax
M3

Front 39

Genitourinary smooth muscle: Uterus symp

Back 39

relaxes (non pregant this dominates)
B2

contracts (only in the pregnant state) a1

Front 40

Genitourinary smooth muscle: Uterus parasymp

Back 40

variable effects

Front 41

Genitourinary smooth muscle: Penis symp

Back 41

ejaculation a1

Front 42

Genitourinary smooth muscle: Penis parasymp

Back 42

erection (NO release) M3

Front 43

Skin: Pilomotor smooth muscle: symp

Back 43

contraction
a1

Front 44

Skin: Pilomotor smooth muscle parasymp

Back 44

no effect

Front 45

Skin: Eccrine (thermoregulatory) Sweat glands symp

Back 45

increases
M3, M2

Front 46

Skin: Eccrine (thermoregulatory) sweat glands parasymp

Back 46

no effect

Front 47

Skin apocrine (stress) sweat glands: symp

Back 47

increases
a1

Front 48

Skin apocrine (stress) sweat glands: parasymp

Back 48

no effect

Front 49

Metabolic functions: Liver symp

Back 49

stimulates gluconeogenesis
B2, A1

Front 50

Metabolic functions: Liver parasymp

Back 50

no effect

Front 51

Metabolic functions: pancrease symp

Back 51

acini -> dec secretion alpha
Islets (B cell) -> dec secretion a2
Islets (B cell) -> inc secretion B2

Front 52

Metabolic functions: pancrease parasymp

Back 52

Acini -> inc secretion
M3, M2

Front 53

Metabolic functions: fat cells symp

Back 53

lipolysis
B3

Front 54

Metabolic functions: Liver parasymp

Back 54

no effect

Front 55

Metabolic functions: Kidney sympathetic

Back 55

inc renin secretion B1
dec renin secretion A1

Front 56

Kidney Sympathetic

Back 56

dilation of renal blood vessels (maintains blood flow) D1

Front 57

Kidney: Parasympathetic

Back 57

no effect

Front 58

Autonomic nerve endings presynaptic receptors:
Sympathetic terminals (dec NE release)

Back 58

Autoreceptor: A2

Heteroreceptor M2, M4

Front 59

Autonomic nerve endings presynaptic receptors:

Parasympathetic terminals (dec ACH release)

Back 59

Autoreceptor M2, M4

Heteroreceptor: A2