Autonomic Nervous System Drugs

Front 1

Acetylcholine (Ach)

Back 1

direct acting cholinergic agonist
very short duration of action
degraded primarily by AchE

Front 2

Methacholine

Back 2

direct acting cholinergic agonist
more selective for M receptors
longer acting than Ach

Front 3

Carbachol

Back 3

direct acting cholinergic agonist
not very selective
used locally (e.g., glaucoma)

Front 4

Bethanechol

Back 4

direct acting cholinergic agonist
long acting
selective for M receptors

Front 5

Muscarine

Back 5

direct acting cholinergic agonist
selective for M receptors

Front 6

Pilocarpine

Back 6

direct acting cholinergic agonist
selective for M receptors

Front 7

Nicotine

Back 7

direct acting cholinergic agonist
selective for N receptors

Front 8

Lobeline

Back 8

direct acting cholinergic agonist
selective for N receptors

Front 9

Cevilemine

Back 9

direct acting cholinergic agonist
selective for M receptors

Front 10

Ach use(s)

Back 10

produces complete miosis in eye surgery

Front 11

Carbachol use(s)

Back 11

produces complete miosis in eye surgery

Front 12

Methacholine use(s)

Back 12

diagnosis of bronchial airway hyperreactivity

Front 13

Bethanechol use(s)

Back 13

bladder and GI hypotonia

Front 14

Muscarine use(s)

Back 14

none

Front 15

Pilocarpine use(s)

Back 15

Glaucoma
Sjogren's syndrome

Front 16

Oxotremorine use(s)

Back 16

used as experimental model of Parkinson's disease tremor

Front 17

chem structure of neostigmine

Back 17

quaternary amine

Front 18

chem structure of physostigmine

Back 18

tertiary amine

Front 19

chem structure of carbaryl

Back 19

tertiary amine

Front 20

chem structure of edrophonium

Back 20

quaternary amine

Front 21

tubocurarine

Back 21

competitive antagonist of Ach
selective for Nm
non-depolarizing neuromuscular blocker

Front 22

Doxacurium

Back 22

competitive antagonist of Ach
selective for Nm
non-depolarizing neuromuscular blocker

Front 23

Pancuronium

Back 23

competitive antagonist of Ach
selective for Nm
non-depolarizing neuromuscular blocker

Front 24

Atracurium

Back 24

competitive antagonist of Ach
selective for Nm
non-depolarizing neuromuscular blocker

Front 25

Succinylcholine

Back 25

non-competitive ("irreversible") cholinergic agonist
selective for Nm
depolarizing neuromuscular blocker
occupies receptor and blocks end plate channel
causes persistent depolarization

Front 26

nicotine

Back 26

direct acting cholinergic agonist
selective for N receptor

Front 27

McN-A-343
(from virtual dog lab)

Back 27

cholinergic agonist
selective for M1

Front 28

Oxotremorine receptor selectivity

Back 28

M1 M2 M3

Front 29

Methacholine receptor selectivity

Back 29

M1 M2 M3

Front 30

Carbamylcholine receptor selectivity

Back 30

M1 M2 M3 Nn

Front 31

Ach receptor selectivity

Back 31

M1 M2 M3 Nn Nm

Front 32

N-methylatropine

Back 32

cholinergic antagonist
nonselective

Front 33

Atropine

Back 33

cholinergic antagonist
selective for M receptor

Front 34

Pirenzepine

Back 34

cholinergic antagonist
selective for M1

Front 35

Tiotropium

Back 35

cholinergic antagonist
selective for M3

Front 36

Hexamethonium

Back 36

cholinergic antagonist
selective for Nn

Front 37

Trimethaphan

Back 37

cholinergic antagonist
selective for Nn

Front 38

Mecamylamine

Back 38

cholinergic antagonist
selective for Nn

Front 39

Tubocurarine selectivity

Back 39

cholinergic antagonist
selective for N

Front 40

direct-acting cholinergic agonist selective for N receptor

Back 40

nicotine

Front 41

2 direct-acting cholinergic agonists that produce complete miosis in eye surgery

Back 41

Ach
Carbachol

Front 42

2 direct-acting cholinergic agonists used for smoking cessation

Back 42

nicotine
lobeline

Front 43

name 6 irreversible indirect-acting cholinergic agonists. these 6 also classified as?

Back 43

echothiaphate
isofluorophate
parathion
malathion
Soman
Sarin
(all 6 are organophosphates)

Front 44

Name 3 drugs used as insecticides

Back 44

parathion
malathion
carbaryl

Front 45

Name 2 drugs used as nerve gases. Class?

Back 45

soman and sarin
organophosphates (irreversible indirect-acting cholinergic agonists)

Front 46

drug used in the diagnosis of myasthenia gravis. class? duration of action?

Back 46

edrophonium
reversible indirect-acting cholinergic agonist
5-15 min DOA

Front 47

name 9 direct-acting cholinergic agonists

Back 47

Ach
Muscarine
Nicotine
Bethanechol
Carbachol
Pilocarpine
Methacholine
Cevimeline
Lobeline

Front 48

name 11 reversible indirect-acting cholinergic agonists

Back 48

carbaryl
ambenomium
edrophonium
neostigmine
physostigmine
pyridostigmine
rivastigmine
oxotremorine
galantamine
tacrine
donepezil

Front 49

2 reversal agents for organophosphates

Back 49

pralidoxime (PAM, Tupam) -- must be given before aging process; doesn't cross BBB
atropine ("heroic" doses) -- crosses BBB to reverse CNS effects

Front 50

8 cholinergic drugs used in the treatment of glaucoma

Back 50

direct-acting:
pilocarpine (most commonly used)
carbechol
methacholine
neostigmine

Indirect-acting:
demecarium (reversible)
physostigmine (reversible)
isofluorophate (irreversible)
echothiaphate (irreversible)

Front 51

4 cholinergic drugs used in the diagnosis and/or treatment of myasthenia gravis

Back 51

edrophonium (diagnosis only)
ambenomium
pyridostigmine
neostigmine

Front 52

2 cholinergic drugs used in the treatment of GI/GU atony

Back 52

neostigmine
bethanecol

Front 53

2 drugs completely resistant to acetylcholinesterase (AchE)

Back 53

Carbachol
Bethanechol

Front 54

1 cholinergic drug moderately resistant to AchE

Back 54

methacholine

Front 55

talsaclidine: class? receptor selectivity?

Back 55

cholinergic agonist
selective for M1
used in Alzheimer's dz

Front 56

Gallamine: class? receptor selectivity? clinical use? undesired effect?

Back 56

competitive cholinergic antagonist
nondepolarizing NM blocker
also has M2 blocking activity (incr HR)