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30 Cards in this Set
- Front
- Back
- 3rd side (hint)
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ADRENERGIC AGONIST (sympathomimetics or adrenergics) |
DRUGS THAT STIMULATE THE SYMPATHETIC NERVOUS SYSTEM.
They mimic the sympathetic neurotransmitter (NT) epinephrine and norepinephrine. |
fight or flight |
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ADRENERGIC RECEPTOR |
ADRENERGICS ACT ON THE RECEPTOR.
LOCATED IN EFFECTOR CELLS OF HEART, BRONCHIOLE WALLS, GI TRACT, URINARY BLADDER, AND CILIARY MUSCLES OF THE EYE |
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FOUR MAIN ADRENERGIC RECEPTORS |
ALPHA 1, ALPHA 2, BETA1, AND BETA 2.
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ALPHA 1 ACT ON |
BLOOD VESSELS, EYE, BLADDER, PROSTATE
IN BLOOD VESSELS VASOCONSTRICT, INCREASE BP AND CONTRACTILITY OF HEART.
PUPIL DILATION IN EYE
RELAXATION OF BLADDER
CONTRACTION OF PROSTATE |
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ALPHA 2 ACT ON |
BLOOD VESSELS AND SMOOTH MUSCLE (GI)
DECREASE BP (REDUCE NE) IN BLOOD VESSELS.
DECREASE GI TONE AND MOTILITY.
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BETA 1 ACT ON |
HEART AND KIDNEY
INCREASE HEART CONTRACTION AND HEART RATE
INCREASE RENIN SECRETION ,ANGIOTENSIN AND BP IN KIDNEY. |
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BETA 2 ACT ON |
SMOOTH MUSCLE (GI), LUNGS, UTERUS, AND LIVER.
DECREASE GI TONE AND MOTILITY.
BRONCHODILATE LUNGS.
RELAX UTERINE SMOOTH MUSCLE.
ACTIVATE GLYCOGENOLYSIS AND INCREASE BLOOD SUGAR IN LIVER. |
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DOPAMINERGIC |
LOCATED RENAL,MESENTERIC,CORONARY AND CEREBRAL ARTERIES.
THE VESSELS DILATE AND BLOOD FLOW INCREASES. |
ONLY DOPAMINE CAN ACTIVATE THIS RECEPTOR. |
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TWO ENZYMES THAT INACTIVATE NOREPINEPHRINE (NE) |
(MAO)-MONOAMINE OXIDASE-INSIDE NEURON
(COMT)- catechol-O-methyltransferase- OUTSIDE NEURON. |
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CATECHOLAMINES |
CHEMICAL STRUCTURES OF A SUBSTANCE (EITHER ENDOGENOUS OR SYNTHETIC) THAT CAN PRODUCE SYMPATHOMIMETIC RESPONSE.
EX: E,NE, DOPAMINE
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NONCATECHOLAMINES |
STIMULATE THE ADRENERGIC RECEPTORS. MOST HAVE A LONGER DURATIONOF ACTION THAN CATECHOLAMINES.
EX: PHENYLEPHRINE, METAPROTERENOL, AND ALBUTEROL |
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ADRENERGIC BLOCKERS (antagonist or sympatholytics) |
DRUGS THAT BLOCK THE EFFECTS OF ADRENERGIC (NT)
They block the alpha and beta receptor sites. |
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SELECTIVE ALPHA BLOCKER |
BLOCK ALPHA 1 |
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NON SELECTIVE ALPHA BLOCKER |
BLOCK ALPHA 1 AND ALPHA 2 |
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ALPHA BLOCKERS |
PROMOTE VASODILATION CAUSING A DECREASE IN BP |
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BETA BLOCKERS |
DECREASE HEART RATE AND BLOOD PRESSURE |
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NONSELECTIVE BETA BLOCKERS |
BLOCK BETA 1 AND BETA 2 |
SHOULD BE USED WITH EXTREME CAUTION WITH COPD OR ASTHMA. |
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SELECTIVE BETA BLOCKER |
DECREASE PULSE RATE AND BP
BLOCK BETA 1 ONLY. |
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ADRENERGIC NEURON BLOCKERS |
BLOCK THE RELEASE OF (NE) FROM SYMPATHETIC TERMINAL NEURONS.
CLINICAL USE: DECREASE BP
EX: RESPERINE |
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WHAT TWO GROUPS OF DRUGS AFFECT THE PARASYMPATHETIC NERVOUS SYSTEM |
CHOLINERGIC AGONIST AND ANTICHOLINERGICS |
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ACETYLCHOINE |
THE NEUROTRANSMITTER LOCATED AT THE GANGLIONS AND THE PARASYMPATHETIC TERMINAL NERVE ENDINGS.
INNERVATES CHOLINERGIC RECEPTORS IN ORGANS TISSUES AND GLANDS.
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TWO TYPES OF CHOLINERGIC RECEPTORS |
MUSCARINIC AND NICOTINIC |
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MUSCURINIC |
STIMULATE (SMOOTH MUSCLE) AND SLOW HEART RATE.
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NICOTINIC |
NEUROMUSCULAR AFFECT THE (SKELETAL MUSCLES) |
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CHOLINERGIC |
-STIMULATE PNS-DECREASE VITAL ORGANS -CARDIAC-DECREASE PULSE AND BP -GI-INCREASE PERISTALISIS -GU-INCREASE URINE -EYE-CONSTRICT PUPIL -LUNG-BRONCHO CONSTRICT
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INDIRECT ACTING CHOLINERGIC AGONIST |
BREAKDOWN CHOLINESTERASE |
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DIRECT ACTING CHOLINERGIC AGONIST |
ACT ON RECEPTORS TO ACTIVATE A TISSUE RESPONSE. |
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ANTICHOLINERGIC |
INHIBIT ACTION OF ACH BY OCCUPYING THE ACH RECEPTORS. |
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MAJOR BODY TISSUES AND ORGANS AFFECTED BY THE ANTICHOLINERGICS |
HEART,RESPIRATORY TRACT, GI TRACT, URINARY BLADDER, EYES AND EXOCRINE GLANDS. |
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MAJOR RESPONSES TO ANTICHOLINERGICS |
DECREASED GI MOTILITY, SALIVATION,DILATION OF PUPILS (MYDRIASIS), INCREASE IN PULSE RATE. |
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