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15 Cards in this Set
- Front
- Back
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Sympathetic outflow
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Thoraco-Lumbar regions
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Parasympathetic outflow
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Cranio-Sacral regions
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Sympathetic gaglia location
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paraverterbral ganglionic chain
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Parasympathetic ganglia location
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in close proximity to target tissue
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Neurotransmitter in ALL ganglionic synapses
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ACh
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Neurotransmitter at sympathetic neuro-effector junctions
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NE; except at sweat glands where postganglionic sympathetic fibers release ACh
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Neurotransmitter at parasympathetic neuro-effector junctions
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ACh
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Target tissue EXCLUSIVELY under sympathetic control
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Peripheral Vascular smooth muscle
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Target tissue under predominant parasympathetic control
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SA Node; GI smooth muscle
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Target tissue with Dual Innervation (Reciprocal Innervation)
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Smooth muscles of the iris
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Termination of NT effects in cholinergic synapses
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Occurs by hydrolysis of ACh by Acetylcholinesterase; acetate diffuses out of synapse and choline is recycled into the presynaptic nerve terminal for resynthesis of ACh by Choline acetylase
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Termination of NT effects in adrenergic synapses
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Occurs primarily by diffucion of NE out of the synaptic cleft; some NE is recycled by reuptake into the presynaptic nerve terminal, subjected to oxidative deamination by MAO and the rest repackaged into vesicles for future release
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Synthesis of amine NTs
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Phe-->Tyr-->DOPA-->DA-->NE; Phenylalanine hydroxylase,Tyrosine hydroxylase, DOPA decarboxylase, DA beta-hydroxylase, respectively
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Pheochromocytoma
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Adrenal Medullary Tumor; Excessive synthesis and paroxysmal secretion of catecholamine neurohormones; NE converted to epinephrine by PEA N-methyl transferase; Hypertensive Crisis
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Phenylketonuria (PKU)
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Caused by genetic deficiency of Phenylalanine hydroxylase; Tyrosine becomes an essential aminoacid; Phe converted to Phenyl pyruvate - a Phenylketone in structure that can cause mental retardation in neonates and infants
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