Autonomic Drugs: Cholinergics/anti-Cholinergics

Front 1

Blocks the choline transporter in neurons

Back 1

Hemicholinium

Front 2

Blocks ChAT (choline acetyltransferase)

Back 2

Vesamicol

Front 3

Bacterial toxin that blocks ACh release at the NMJ

Back 3

botulinum toxin

Front 4

Blocks conversion of tyrosin to Dopa

Back 4

Metyrosine

Front 5

Blocks conversion of dopamine to norepinephrine

Back 5

Reserpine

Front 6

Blocks NE release from nerve terminals

Back 6

Guanethidine

Front 7

Stimulates NE release from nerve terminals

Back 7

Amphetamine

Front 8

Blocks NE reuptake at nerve terminals

Back 8

Cocaine, tricyclic antidepressants, amphetamine

Front 9

Activates bowel and bladder smooth muscle

Back 9

Bethanechol
DIRECT CHOLINOMIMETIC (M3)

Front 10

Used for glaucoma, pupillary contraction, and release of intraocular pressure

Back 10

Carbachol
DIRECT CHOLINOMIMETIC (M3)

Front 11

Contracts ciliary muscle of eye (open angle) and pupillary sphincter (narrow angle); resistant to ACh
Stimulates sweat, tears, saliva

Back 11

Pilocarpene
DIRECT CHOLINOMIMETIC (M3)

Front 12

Administered as challenge test for diagnosis of asthma

Back 12

Methacholine
DIRECT CHOLINOMIMETIC (M3)

Front 13

Postoperative and neurogenic ileus, urinary retention, myasthenia gravis, reversal of NMJ blockade
No CNS penetration

Back 13

Neostigmine
INDIRECT CHOLINOMIMETIC
(ACH ESTERASE BLOCKER)

Front 14

Long acting for myasthenia gravis
No CNS penetration

Back 14

Pyridostigmine
INDIRECT CHOLINOMIMETIC
(ACH ESTERASE BLOCKER)

Front 15

Diagnosis of myasthenia gravis

Back 15

Edrophonium
INDIRECT CHOLINOMIMETIC
(ACH ESTERASE BLOCKER)

Front 16

Used for glaucoma (can penetrate the CNS), reversal of atropine overdose

Back 16

Physostigmine ("PHYS for EYES")
INDIRECT CHOLINOMIMETIC
(ACH ESTERASE BLOCKER)

Front 17

Indication for echothiophate
INDIRECT CHOLINOMIMETIC
(ACH ESTERASE BLOCKER)

Back 17

glaucoma

Front 18

Antidote for organophosphate poisoning

Back 18

Atropine (muscarinic antagonist)
Pralidoxime (replenishes endogenous acetylcholinesterase)

Front 19

Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle/CNS, Lacrimation, Sweating, Salivation

Back 19

DUMBBELSS (cholinergic side effects)

Organophosphate poisoning

Front 20

Agents used to dilate eyes and induce cycloplegia (no accommodation)

Back 20

Atropine, homatropine, tropicamide

Front 21

Muscarinic antagonist used in Parkinson's disease

Back 21

Benztropine (PARK my BENZ)
MUSCARINIC ANTAGONIST

Front 22

Given for motion sickness

Back 22

Scopolamine
MUSCARINIC ANTAGONIST

Front 23

Muscarinic antagonist used for asthma and COPD

Back 23

ipratropium

Front 24

oxybutynin
glycopyrrolate

Back 24

Muscarinic antagonists used to reduce urgency in mild cystitis and reduce bladder spasms

Front 25

Methscopolamine
Pirenzepine
Propantheline

Back 25

Muscarinic antagonists used in peptic ulcer treatment

Front 26

Atropine toxicity

Back 26

Red as a beet
Dry as a bone (dry mouth)
Blind as a bat (clycloplegia)
Mad as a hatter (disorientation)
Hot as a hare

Plus acute-angle glaucoma, urinary retention, hyperthermia in infants

Front 27

Side effects of the drug used to prevent vagal reflex responses to changes in blood pressure

Back 27

Hexamthonium (nicotinic antagonist)

orthostatic hypotension, blurred vision, constipation, sexual dysfunction