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51 Cards in this Set

  • Front
  • Back

Bethanechol

muscarinic agonist

Carbachol

muscarinic agonist

methacholine

muscarinic agonist



pilocarpine

muscarinic agonist



Donepezil

Anticholinesterase (indirect agonist)

Galanatmine

Anticholinesterase (indirect agonist)

Rivastigmine

Anticholinesterase (indirect agonist)



Edrophonium

Anticholinesterase (indirect agonist)

Neostigmine

Anticholinesterase (indirect agonist)



Physostigmine

Anticholinesterase (indirect agonist)



Pyridostigmine

Anticholinesterase (indirect agonist)

Drug for sjogren's pt that is very dry (potent stimulator of sweat, tears, saliva)


Also for open angle and closed angle glaucoma

Pilocarpine

Activates bowels and bladder

Bethenecol

Acetylcholinesterases used in alzheimers

Rivastigmine, Galantamine, Donepezil

Dx of Myasthenia Gravis (extremely short acting) Myasthenia now dx by anti-achR antibody test

Edrophonium

Post-op reversal of nmj blockade to get bowels and bladder going again; No CNS penetration

Neostigmine

Atropine OD

Physostigmine

Tx of myasthenia gravis, does not penetrate CNS

Pyridostigmine

which autonomic drugs exacerbate COPD, Asthma, peptic ulcers?

cholinomimetics

most fatal side effect of cholinomimetics and antidote

1.excitation- you can stop breathing from xs excitation of diaphragm


2. atropine



Regenerates AchE in case of toxicity by ache inhibitors

pralidoxime

Atropine


Benztropine


homatropine

Muscarinic Antagonist

Tropicamide

Muscarinic Antagonist

Dicyclomine, Hyocyamine

Muscarinic Antagonist

Glycopyrrolate

Muscarinic Antagonist

Ipratropium, Tiotropium

Muscarinic Antagonist

Oxybutynin

Muscarinic Antagonist

Solifenacin

Muscarinic Antagonist

Tolterodine

Muscarinic Antagonist

Scopolamine

Muscarinic Antagonist

Use for eye exams

Tropicamide

Use for Parkinson's Dz

Benztropine

Used pre-op to reduce airway secretions or orally to tx peptil ulcer

glycopyrrolate

Tx of COPD

ipratropium, tiotropium

reduces bladder spasm and urge urinary incontinenece

oxybutynin, solifenacin, tolterodine

treats motion sickness (CNS)

scopolamine

Action of Muscarinic antagonists

inhibit parasymp action at M receptos


M1-brain


M2-heart


M3-everything else


decreases secretions, motility,


mydriasis

What does Epi effect more and when?

a1,a2,b1,b2


b>a


alpha predominates at high doses

receptor for increased renin release

b1

receptor for increased lipolysis

b1 and 2

receptor for decreased lipolysis

a2

receptor for mydriasis

a1

receptor for increased intestinal and bladder muscle contraction

a1

receptor for ciliar muscle relaxation

b2

receptor for decreased uterine tone (tocolysis)

b2

receptor for decreased sympathetic outflow, decreased aqueous humor production

a2

receptor that relaxes renal vascular smooth muscle

d1

phenoxybenzine

irreversible a blocker

use of phenoxybenzamine

pheochromocytoma preop to prevent catecholamine hypertensive crisis

phentolamine

reversible a blocker

use of phentolamine

give to pts on MAO inhibitors who eat tyramine containing foods