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31 Cards in this Set

  • Front
  • Back
where are nicotinic receptors found
autonomic ganglia, adrenal gland, and skeletal muscle
enzyme that breaks down Ach
Achesterase
precursors to NE
tyrosine to DOPA to dopamin
where are muscarinic receptors found
parasymp end organs, brain, sweat glands, salivary glands, heart, GI smooth muscle, eye
location and effect of alpha 1 adrenergic
blood vessels (constriction), urinary sphincters, eye (dilation)
location and effect of alpha 2 adrenergic
slows down activation of symp, end organs
location and effect of beta1 adren
heart (increase rate and force), kidney, brain
location and effect of beta2
airways (relaxation/dilation), blood vessels of skeletal muscle (dilation), pregnant uterus (use agonist to slow down premature contractions
which enzyme metabolizes dopamine, norepi, and epi
catechol-O-methyltransferase

inhibit this for Parkinson
describe monamine oxidases
A is in the gut and some peripheral tissues, while B is in the brain. Inhibit this to increase brain neurotransmitters
sympathetic NS is sole innervation of
vascular smooth muscle (alpha1&beta2)
MOA of cholinergic agonists
mimick Ach or inhibit Achesterase
bethanechol (Urecholine)
GU, helps urinate but SE is diarrhea
methacholine
inhaled to induce bronchoconstriction/cough
used to diagnose Reactive Airway disease. Normal folks just cough a little
list direct cholinergic agonists
bethanechol, methacholine, pilocarpine
pilocarpine
induces salivation and/or tearing of eyes
list Achesterase inhibitors
edrophonium, pyridostigmine, physostigmine
edrophonium
diagnostic of myasthenia gravis. Ach receptors on skeletal muscle are blocked by antibodies.
pyridostigmine
treatment for MG. oral Achesterase inhibitor
physostigmine
for people who don’t wake up from paralytic drugs
MOA of cholinergic antagonists
blocks muscarinic receptor
list cholinergic antagonists
atropine, benztropine (Cogentin), trihexyphenidyl (Artane)

others
atropine
treat bradycardia, dries secretions in mouth and lungs for procedures (bronchoscopy)
benztropine (Cogentin)
relief of tremors in patients with Parkinson, treats side effects of drugs that are given in bipolar disorder
trihexyphenidyl (Artane)
relief of tremors in patients with Parkinson, treats side effects of drugs that are given in bipolar disorder
dicyclomine (Bentyl)
“calms” GI tract with anxiety disorders (irritable bowel syndrome)
ipratropium (Atrovent)
for COPD, mild bronchodilators
tiotropium (Spiriva)
for COPD
oxybutynin (Ditropan, Ditropan XL, Oxytrol patch)
tolterodine (Detrol, Detrol LA)
darifenacin (Enablex)
solifenacin (Vesicare)
trospium (Sanctura)
all for bladder irritability/ urine incontinence
scopolamine (Transderm SCOP)
carsick etc. dries secretions
glycopyrrolate (Robinul)
procedural for drying secretions