Autoimmune Dieases

Front 1

Autoimmune Dysfunction

Back 1

assoc. w/ a loss of self-tolerance, resulting in immune reactions directed against host tissue

Front 2

Mechanisms of autoimmunity

Back 2

1- Release of normally sequestered antigens (sperm)
2- Sharing of antigens between host and pathogen
3- Defects in functions of helper or suppressor T cells
4- Persistence of autoreactive T and B cells
5- Presence of specific autoab

Front 3

Systemic Lupus Erythematosus

Back 3

Connective tissue dz mainly affects the blood, joints, skin and kidneys
1. Occurs predominately in women of childbearing age

Front 4

SLE Pathogenesis

Back 4

Polyclonal B-cell acivation, sustained estrogen activity , environmental triggers

Front 5

SLE Clinical Findings
Hematologic

Back 5

Autoimmune hemolytic anemia, thrombocytopenia, leukopenia

Front 6

SLE Clinical Findings
Lymphatic

Back 6

1. Generalized painful LAD
2. Splenomegaly

Front 7

SLE Musculoskeltal Findings

Back 7

Small-joint inflammation (e.g., hands) w/ absence of joint deformity

Front 8

SLE Skin Findings

Back 8

1. Immunocomplex deposition along basement membrane
--Prodces liquefactive degeneration
2. Malar Butterfly Rash

Front 9

SLE Renal Findings!

Back 9

Diffuse proliferative glomerulonephritis ( most common glomerulonephritis)

Front 10

SLE Cardiovascular

Back 10

1. Fibrinous pericarditis w/ or w/o effusion
2. Libman-Sacks endocarditis (sterile vegetations on Mitral valve0