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10 Cards in this Set
- Front
- Back
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Marker for histamine excess in the body
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Imidazoleacetic acid in the urine
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Names & Uses of first generation antihistamines
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Diphenydramine, Promethazine, Chlorpheniramine, Meclizine, Hydroxyzine
-antiemetic (prophylactic for motion sickness), antivertigo, local anesthetic, and antitussive |
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Drug interactions involving terfinadine and astemazole
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-Effects on cardiac K+ channels (prolong QT interval)
-Ketoconazole or macrolide antibiotics cause an increase in blood conc. of antihistamines |
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Marker for serotonin levels in the body
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5HIAA elevated in carcinoid syndrome
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Marker for serotonin levels in the body
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5HIAA elevated in carcinoid syndrome
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MOA of “triptans”
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5HT1d agonist
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Rx of acute migraine
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NOTE
NSAIDs, opiods, ergotamine and “triptans” (sumatriptan) |
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Drugs used in prophylaxis of migraine
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PAMVV
propanolol, verapamil, methysetgide (ergot), amitryptilline, and valproic acid |
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Drugs used to prevent PPH-postpartum hemorrhage (ergots)
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Erogonovine
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MOA Sildenafil and drug interactions with nitrates
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MOA: increase cGMP by inhibiting its breakdown by phosphodiesterase isoform 5
-Sildenafil potentiates action of nitrates causing severe hypotension and myocardial infarctions in some people |
