Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
|
Typical Locations of:
M1 receptors |
Autonomic ganglia
CNS |
|
|
Typical Locations of:
M2 receptors |
Heart: SA node, AV node, atrium, ventricle
|
|
|
Typical Locations of:
M3 receptors |
Smooth muscle
|
|
|
Typical Locations of:
M4 receptors |
CNS
|
|
|
Typical Locations of:
M5 receptors |
CNS
|
|
|
Typical Locations of:
Nm receptors |
Skeletal muscle at NMJ
|
|
|
Typical Locations of:
Nn receptors |
Autonomic ganglia, Adrenal medulla, CNS
|
|
|
Responses to:
M1 |
late EPSP
(arousal, attention, analgesia) |
|
|
Responses to:
M2 |
Slowed spontaneous depol; hyperpol.
Low conduction velocity Low refractory period Low contractile force Low contractility |
|
|
Responses to:
M3 |
Contraction
|
|
|
Responses to:
Nm |
End-plate depolarization
Skeletal muscle contraction |
|
|
Responses to:
Nn |
Depolarization and firing of postganglionic neuron, Secretion of catecholamine,
(arousal, attention, and analgesia) |
|
|
Mechanism of action for:
M1 |
G-protein > PLC > IP3 > DAG > Ca + PKC
|
|
|
Mechanism of action for:
M2 |
G-protein > inhibit AC + opens K channels
|
|
|
Mechanism of action for:
M3 |
G-protein > PLC > IP3 > DAG > Ca + PKC
|
|
|
Mechanism of action for:
M4 |
G-protein > inhibit AC + opens K channel
|
|
|
Mechanism of action for:
M5 |
G-protein > PLC > IP3 > DAG > Ca + PKC
|
|
|
Mechanism of action for:
Nm |
Opening Na/K channels
|
|
|
Mechanism of action for:
Nn |
Opening Na/K channels
|
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
Arterioles |
Sympathetic (adrenergic)
Vasodilation;Increased peripheral blood flow; hypotension |
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
Veins |
Sympathetic (adrenergic)
Vasodilation; pooling of blood; decreased venous return; decreased cardiac output |
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
Heart |
Parasympathetic (cholinergic)
Tachycardia |
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
Iris |
Parasympathetic (cholinergic)
Mydriasis (pupil dilation) |
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
Ciliary muscle |
Parasympathetic (cholinergic)
Cycloplegia (far vision) |
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
GI tract |
Parasympathetic (cholinergic)
decreased tone and motility; constipation; decreased secretions |
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
Urinary bladder |
Parasympathetic (cholinergic)
Urinary retention |
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
Salivary glands |
Parasympathetic (cholinergic)
Xerostomia (dry mouth) |
|
|
Effects of Autonomic Ganglionic Blockade on Tissue:
Sweat glands |
Sympathetic (cholinergic)
Anhidrosis (absence of sweating) |
|
|
Adrenoreceptor actions:
alpha-1 (Gq/Go/Go) |
1. Vascular smooth muscle-contraction
2. Genitourinary smooth muscle-contraction 3. Intestinal smooth muscle-relaxation 4. Heart-increased inotropy and excitability 5. Liver-glycogenolysis and gluconeogenesis |
|
|
Adrenoreceptor actions:
alpha-2 (Gj/Go) |
1. Pancreatic beta-cells-decreased insulin secretion
2. Platelets-Aggregation 3. Nerve-decreased norepinephrine release 4. Vascular smooth muscle-contraction |
