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23 Cards in this Set
- Front
- Back
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histamine antagonist (release inhibitors)
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Cromolyn, nedocromil, B2 agonists
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terfenadine or astemizole
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H1 receptor antagonist; caused ventricular arrhythmias when taken with CYP3A4 inhibitors
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H2 receptor antagonists
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cimetidine, ranitidine, famotidine, nizatidine.
Uses: peptic ulcers, acute stress ulcers, GERD Adverse: cimetidine inhibits cytochrome P450, also has antiandrogenic effects (gynecomastia, reduced sperm count, galactorrhea) |
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Sumatriptan
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5HT(1D/1B) receptor agonist; acute severe migrane attacts
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Metoclopramide
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prokinetic agent; results in coordinated contractions that enhance transit
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Cisapride
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5HT(4) receptor agonist; prokinetic, serious cardiac adverse effects (no longer available in the US)
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Tegaserod
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5HT(4) partial agonist; irritable bowel syndrome with constipation; withdrawn from US due to increased risk of CV effects
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Cyproheptadine
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5HT(2) antagonist; potent H1 blocking actions
Tx: allergic rhinitis, vasomotor rhinitis, cold urticaria, dermatographism, treatment of sm muscle manifestations of carcinoid tumor, serotonin syndrome |
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5HT(3) receptor antagonists
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Ondansetron
Granisetron Palonosetron Dolasetron Tx: anti-emetics, useful with cancer chemo |
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Ergot alkaloids
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affect a adrenoceptors, dopamine receptors, 5HT receptors
Tx migraine pain |
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Bromocriptine
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Ergot alkaloid
reduces high levels of prolactin from pituitary tumors Cabergoline--more potent |
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Ergonovine maleate
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Ergot alkaloid
useful for postpartum hemorrhage |
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Ergonovine
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Ergot alkaloid
provokes coronary artery spasm in patients with variant angina (useful in diagnosis) |
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Dinoprostone
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eicosanoid
ripen cervix at term before induction of labor with oxytocin w/carboprost tromethamine--abortifacients |
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Misoprostol
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eicosanoid, derivative of PGE1
used with antiprogestin mifepristone or w/methotrexate as abortifacient |
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Alprostadil
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eicosanoid, PGE1
maintains patency of ductus arteriosus used for impotence |
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Prostacyclin
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eicosanoid, PGI2
severe pulm HTN, prevent platelet aggregation in dialysis machines |
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Misoprostol
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eicosanoid
prevention of peptic ulcers in pts who take high doses of NSAIDs for arthritis |
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Latanoprost
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eicosanoid, PGF2 alpha deriv
used for glaucoma newer drugs: bimatoprost, travoprost, unoprostone |
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Zileuton
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eicosanoid antagonist
inhibits 5-lypoxygenase |
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Zafirlukast
Montelukast |
eicosanoid antagonist
LTD4 receptor antagonist |
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Corticosteroids
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eicosanoid antagonist
inhibit production of arachidonic acid by phospholipase in membrane also inhibit synthesis of COX-2 |
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NSAIDs
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eicosanoid antagonist
antipyretic, analgesic, anti-inflammatory inhibit cyclooxygenases |
