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14 Cards in this Set
- Front
- Back
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Where is histamine found in the body?
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- in mast cells and basophils (in secretory granules bound to a proteoglycan
- also as NT or neuromodulator |
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What are the effects of H1 receptor stimulation?
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- smooth muscle (usually contraction)
- pain and itching, catecholamine secretion |
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What are the effects of H2 receptor stimulation?
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- gastric acid secretion
- vasodilatation - inhibition of IgE mediated degranulation |
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Difference between first and second generation H1 blocking agents
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first generation cause sedation.. second generation do not
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Use of H1 blockers
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- mainly to treat allergic reactions (rhinitis, urticaria, drug reactions)
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diphenhydramine
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first generation H1 blocker
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loratadine
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second generation H1 blocker
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primary use of H2 blocking agents
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to treat ulcers
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sources of endogenous 5-HT (serotonin)
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enterchromaffin cells (mostly)
platelets brain |
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buspirone
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5-HT agonist
reduces anxiety |
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sumatryptan
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5-HT agonist for migraine headache
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ondasetron
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5-HT antagonist for nausea and vomiting
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ketanserin
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5-HT antagonist to treat hypertension
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eicosanoid synthesis
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phospholipid -> arachidonic acid -> prostaglandins and leukotrienes
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