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17 Cards in this Set
- Front
- Back
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Pain Mediating Chemicals |
Substance P Prostaglandins Bradykinins Histamine Cellure damage stimulates pain impulses which releases these. |
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Body's Natural Pain Killers |
Serotonin Enkephalins Endorphins Bind with opioid receptors and inhibit pain production or decrease pain. |
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3 opioid receptors |
MU: Analgesia, sedation, euphoria, resp. depression, and physical dependence. KAPPA:Analgesia, sedation, psychic effects mimic pyschosis. DELTA: No pharm. related effects. |
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Inflammation |
Occurs secondary to injury Pain, Inflammation, fever, edema Chem. mediators: bradykinins, histamines, and prostaglandins. |
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Suppression of Inflammation |
Hypothalamus stimulates pit. gland to make ACTH (adrenal cortico tropic hormone) which stimulates adrenal gland to make (glucocorticoids) cortisol and (mineralcorticoids)aldosterone (affects fluid balance) |
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2 Types of analgesics and 2 types of anti-inflammatories: |
Analgesics: NSAIDS- Interfere w/ productions of prostaglandins OPIODS- stim. opioid receptors Anti-Inflam: Glucocorticoids Uricosurics-decrease uric acid in body to prevent gout. |
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4 Types of nonopioid analgesics |
1st gen NSAIDs COX 1, COX 2 inhibitors 2nd gen NSAIDs COX 2 inhibitors acetaminophen (Tylenol) Centrally acting nonopioids |
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1st Gen NSAIDs Cox 1/ Cox 2 inhibitors |
Analgesia for mild-moderate pain Inflam. suppression Fever reduction Dysmenorrhea Inhibition of platelet aggregation (aspirin) |
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2nd Gen NSAIDs Cox 2 Inhibitors |
Analgesia for mild-mod pain Fever reduction Dysmenorrhea Inflam. suppression |
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Acetaminophen |
Reduces fever Analgesic for mild-mod pain |
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Centrally acting non-opioids |
Treat mod-mod severe pain. |
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2 types of analgesics that support t/m of pain: |
Opioid agonist: Bind to MU receptors Opioid agonist-antagonist: Not as effective at reducing pain. Bc it cancels out its effect. MU and Kappa receptors. For women in labor or those who are addicted to opioids. |
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Opioid Agonist: |
Analgesia for moderate to severe pain. Pre- op sedation & reduction of anxiety. |
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Opioid agonist-antagonist: |
Analgesia for moderate to severe pain. Anesthesia adjunct. |
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Opioid antagonist: |
Reverse effects of opioids. Resp depression OD Euphoria Constipation |
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Uricosurics: |
Treat hyperuricemia which causes gout and that occur secondary to chemo therapy and blood dyscrasias. |
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Glucocorticoids: |
Provide symptomatic relief of pain and inflammation for autoimmune disorders and inflam. disorders. Manages skin d/s and allergic reactions Delays progression of SOME disorders, ex: rheumatoid arthritis. Prevents organ rejection. |
