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31 Cards in this Set
- Front
- Back
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Benzodiazipine prototype
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alprazolam (Xanax)
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diazepam (Valium)
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benzodiazipine
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lorazepam (Ativan)
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benzodiazipine
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chlordiazepoxide (Librium)
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benzodiazipine
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chlordiazepoxide (Librium)
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benzodiazipine
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clorazepate (Tranxene)
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benzodiazipine
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oxazepam (Serax)
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benzodiazipine
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clonazepam (klonopin)
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benzodiazipine
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MOA benzodiazipine
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enhances inhibitory effects of gamma-aminobutyric acid in CNS.
Relief from anxiety occurs rapidly follwoing administration |
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benzodiazipine use
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generalized anxiety disorder, panic disorder
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benzodiazipine Adverse effects
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CNS depression, anterograde amnesia, acute toxicity, oral toxicity , pardoxical response, withdrawal symptoms
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benzodiazipine contraindications
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sleep apnea, respiratory depression, glaucoma, liver disease, mental illness, substance abuse disorder
used short-term due to dependence risk |
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benzodiazipine interactions
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CNS depressants
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benzodiazipine nursing administration
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avoid abrupt discontinuation
taper dose over a period of weeks do not crush or chew tablets notify provider if withdrawal symptoms occur |
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atypical anxiolytic/nonbariturate anxiolytic
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prototype: buspirone (Buspar)
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MOA atypical anxiolytic
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binds to serotonin and dopamine receptors
does not result in sedation or potentiate the effects of other CNS depressants |
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atypical anxiolytic uses
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panic disorder, social anxiety disorder, obsessive compulsive disorder, trauma and stressor disorders (PTSD)
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atypical anxiolytic adverse
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dizziness, nausea, headache, lightheadedness, agitation
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atypical anxiolytics contraindications
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breastfeeding
liver or renal dysfunction MAOI or 14 days after MAOI- hypertensive crisis may result |
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atypical anxiolytic interactions
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erythromycin, ketoconazole, St. John's Wort, grapefruit juice may increase effects of buspirone
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SSRIs
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prototype: paroxetine (Paxil)
indicated for GAD, panic disorder |
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sertraline (Zoloft)
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SSRI
indicated for panic disorder, OCD, social anxiety disorder, PTSD |
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escitalopram (Lexapro)
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SSRI
indicated for GAD, OCD |
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fluoxetine (Prozac)
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SSRI
indicated for panic disorder and OCD |
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fluvoxamine (Luvox)
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SSRI
OCD and social anxiety disorder |
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SSRI MOA
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selectively inhibits serotonin reuptake, allowing more serotonin to stay at the junction of the neurons
does not block reuptake of dopamine or norepinepherine produces CNS stimulation long-effective half-life- up to 4 weeks to see results |
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SSRI adverse
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nausea, diaphoresis, tremor, fatigue, drowsiness
sexual dysfunction, decreased sexual interest, weight gain, GI bleeding, hyponatremia, serotonin syndrome, bruxism, withdrawal syndrome |
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SSRI contraindications
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MAOIs, TCAs, alcohol, liver or renal dysfunction, seizure disorders, history of GI bleed
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SSRI interactions
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MAOI or TCA can cause serotonin syndrome
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SSRI administration
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sleep disturbances are minimized by taking meds in the morning
take daily to establish therapeutic levels can take up to 4 weeks to see results |
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SSRI effectiveness
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maintain normal sleep pattern
less anxious and more relaxed ability to participate in social and occupational interactions |
