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19 Cards in this Set
- Front
- Back
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NSAIDS (first generation COX1 and COX 2 inhibitors)
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aspirin
ibuprofen naproxen (Naprosyn) indomethacin (Indocin) diclofenac ketorolac (Sprix) meloxicam (Mobic) |
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NSAIDS (first gen) MOA
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inibition of cyclooxygenase
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COX 1 inhibitor MOA
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results in decreased platelet aggregation and kidney damage
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COX 2 inhibitor MOA
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decreased inflammation, fever, pain
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NSAIDS USE
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inflammation suppression, analgesia, fever reduction, dysmenorrhea, inhibition of platelet aggregation, which protects against ischemic stroke and myocardial infarction
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NSAIDS Adverse
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GI discomfort
damage to gastric mucosa GI bleeding, perforation renal dysfunction increased risk of heart attack or stroke salicylism (tinnitus, sweating, headache, dizziness, respiratory alkalosis Reye syndrome aspirin toxicity |
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NSAIDS contraindications
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peptic ulcer disease
bleeding disorders hypersensitity to asprin and other NSAIDS chicken pox or influenza celexicob- allergies to sulfanomides ketorolac- advanced renal dysfunction- should be used no longer than 5 days second gen NSAIDS shoud be used cautiously in those with cardiovascular disease |
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NSAIDS second gen COX 2
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celexicob (Celebrex)
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NSAIDS interactions
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anticoagulants such as heparin and warfarin increase risk of bleeding
glucocorticoids increase risk of gastric bleeding alcohol increases risk of bleeding ibuprofen ketorolac and other NSAIDS concurrently |
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NSAIDS effectiveness
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reduction in inflammation, fever
relief from mild to moderate pain absence of injury |
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acetaminophen
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proto: acetaminophen (Tylenol)
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acetaminophen MOA
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slows production of prostaglandins in CNS
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acetaminophen USe
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analgesic effect
antipyretic effects |
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acetaminophen adverse
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acute toxicity results in liver damage with early symptoms of nausea, vomiting, diarrhea, sweating and abdominal discomfort progressing to hepatic failure, coma and death
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acetaminophen interventions
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do not exceed 4 g/day
antidote: acetylcysteine (Mucomyst) |
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acetaminophen contraindications
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caution to those who consume three or more alcoholic beverages per day
warfarin |
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acetaminophen interactions
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alcohol
warfarin- increases bleeding risk |
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acetaminophen admin
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take only one product containing acetominophen at a time
administer actylcysteine as an antidote for acetominophen |
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acetaminophen effectivenss
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relief of pain
reduction of fever |
