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19 Cards in this Set

  • Front
  • Back
NSAIDS (first generation COX1 and COX 2 inhibitors)
naproxen (Naprosyn)
indomethacin (Indocin)
ketorolac (Sprix)
meloxicam (Mobic)
NSAIDS (first gen) MOA
inibition of cyclooxygenase
COX 1 inhibitor MOA
results in decreased platelet aggregation and kidney damage
COX 2 inhibitor MOA
decreased inflammation, fever, pain
inflammation suppression, analgesia, fever reduction, dysmenorrhea, inhibition of platelet aggregation, which protects against ischemic stroke and myocardial infarction
NSAIDS Adverse
GI discomfort
damage to gastric mucosa
GI bleeding, perforation
renal dysfunction
increased risk of heart attack or stroke
salicylism (tinnitus, sweating, headache, dizziness, respiratory alkalosis
Reye syndrome
aspirin toxicity
NSAIDS contraindications
peptic ulcer disease
bleeding disorders
hypersensitity to asprin and other NSAIDS
chicken pox or influenza
celexicob- allergies to sulfanomides
ketorolac- advanced renal dysfunction- should be used no longer than 5 days
second gen NSAIDS shoud be used cautiously in those with cardiovascular disease
NSAIDS second gen COX 2
celexicob (Celebrex)
NSAIDS interactions
anticoagulants such as heparin and warfarin increase risk of bleeding
glucocorticoids increase risk of gastric bleeding
alcohol increases risk of bleeding
ketorolac and other NSAIDS concurrently
NSAIDS effectiveness
reduction in inflammation, fever
relief from mild to moderate pain
absence of injury
proto: acetaminophen (Tylenol)
acetaminophen MOA
slows production of prostaglandins in CNS
acetaminophen USe
analgesic effect
antipyretic effects
acetaminophen adverse
acute toxicity results in liver damage with early symptoms of nausea, vomiting, diarrhea, sweating and abdominal discomfort progressing to hepatic failure, coma and death
acetaminophen interventions
do not exceed 4 g/day
antidote: acetylcysteine (Mucomyst)
acetaminophen contraindications
caution to those who consume three or more alcoholic beverages per day
acetaminophen interactions
warfarin- increases bleeding risk
acetaminophen admin
take only one product containing acetominophen at a time
administer actylcysteine as an antidote for acetominophen
acetaminophen effectivenss
relief of pain
reduction of fever