Ati Meds For Pain And Inflammation (Miscellaneous Pain Meds)

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antigout meds antiinflammatory

Back 1

proto: colchicine (Colcrys)

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antigout meds colchicine (Colcrys) antiinflammatory MOA

Back 2

decreases inflammation
colchicine is only effective for inflammation of gout

Front 3

antigout meds colchicine (Colcrys) use

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abort an acute gout attack in response to precursor symptoms
treatment of and decrease incidence of acute attacks for clients who have chronic gout
predinisone is used for clietns with acute gout who are unable to take or unresponsive to NSAIDS

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hyperuricemia agents

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proto: allopurinol (Zyloprim)
other meds: febuxostat (Uloric), probenecid

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hyperuricemia agents MOA

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allopurinol and febuxostat inhibit uric acid production
probencid inhibits uric acid reabsorption by renal tubules

Front 6

hyperuricemia uses

Back 6

hyperuricemia due to chronic gout or secondary to cancer chemotherapy

Front 7

colchicine adverse (antigout)

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GI distress, thormbocytopenia, suppressed bone marrow
muscle pain
tenderness

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probenecid adverse (hyperuricemia)

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renal calculi

Front 9

allopurinol adverse (hyperuricemia)

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hypersensitivity reaction, rash, fever
kidney injury
hepatitis
GI distress

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colchine contraindications (antigout)

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older adults, clients who are debilitated, renal, cardiac, and hepatic or GI dysfunction

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probenecid (hyperuricemia) adverse

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preciptiate acute gout
do not give within 2-3 weeks of an acute attack

Front 12

allopurinol (hyperuricemia) adverse

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idiopathic hemachromatosis
rhabdomyolysis is most likely with long-term use, risk is higher in clients taking statins for high cholesterol and those who have impaired kidneys and liver

Front 13

colchicine interactions

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grapefruit juice

Front 14

probenicid interactions

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salicylates may lessen the effectiveness of probenecid and may precipitate gout

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allopurinol interactions

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slows metabolism of warfarin within the liver, which places clients at risk for bleeding- monitor for signs of bleeding
monitor prothrombin time and INR levels and adjust warfarin dosages accordingly

Front 16

antigout meds admin

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monitor uric acid levels, CBC, uric acid levels, urinalysis, liver and kidney function tests
allopurinol should be well-diluted and administered as an infusion over 30-60 min
avoid alcohol and food high in purine (red meat, scallops, cream sauces)

Front 17

antigout meds effectiveness

Back 17

decrease in number of gout attacks
decrease in uric acid levels

Front 18

migraine meds MOA

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prevent inflammation and dilation of the intracranial blood vessels thereby relieving migraine pain

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migraine meds MOA

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prevent inflammation and dilation of intracranial blood vessels, thereby relieving migraine pain

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migraine meds use

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NSAIDS, and combination anti-inflammatory meds, ergotamine, and triptans are used to stop a migraine after it begins

beta-blockers, anticonvulsants, amitriptyline, calcium-channel blockers and estrogens prevent a migraine headache

Front 21

ergot alkaloids (migraine meds) adverse
ergotamine and dihydroergotamine

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GI discomfort- administer metoclopramide (Reglan)
ergotism (muscle pain, paresthesias in fingers and toes; cold, pale extremties)
physical dependence
fetal abortion

Front 22

serotonin receptor antagonist (triptans) sumatriptan adverse

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chest pressure
coronary artery vasospasm, angina
dizziness or vertigo

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beta-blockers propranolol adverse

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extreme tiredness, fatigue, depression, and asthma exacerbation
bradycardia, hypotension

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anticonvulsants: divalproex adverse

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neural tube defects
liver toxicity
pancreatitis

Front 25

TCAs amitriptyline adverse

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anticholinergic effects
drowsiness or dizziness

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calcium channel blockers verapamil adverse

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orthostatic hypotension or bradycardia
constipation

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migraine meds contraindications (ergotamine)

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renal or liver dysfunction, sepsis, hypertension, history of MI and CAD, pregnancy

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triptans contraindications

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liver failure, ischemic heart disease, MI, hypertension

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propranolol contraindications

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greater than first-degree heart block, bradycardia, bronchial asthma, cardiogenic shock, HF
caution: taking other antihypertensives or who have liver or renal impairment, DM, Wolf-Parkinson- White syndrome

Front 30

divalproex sodium (Depakote) contraindications

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liver disease

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amitriptyline (Elavil) contraindications

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recent MI or within 14 days of MAO inhibitor
caution: seizure history, urinary retention, prostatic hyperplasia, angle-closure glaucoma, hyperthyroidism,

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verapamil (Calan) contraindications

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greater than first degree heart block, bradycardia, hypotension, left ventricle disease, atrial fibrillation or flutter, HF
caution: liver, renal impairment or increased intracranial pressure

Front 33

ergotamine and dihydroergotamine interactions

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concurrent use with any of the triptans may cause cardiac ischemia- triptans should be taken at least 24 hours apart from ergotamines
some HIV protease inhibitors, antifungal meds, and macrolide antibiotics may increase ergotamine levels, causing increased vasospasm

Front 34

sumatriptan interactions

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concurrent use of MAOI can lead to MAO toxicity
concurrent use with ergotamine or other triptan can cause vasoconstriction and cardiac ischemia
SSRIs taken with triptans may cause serotonin syndrome

Front 35

propranolol interactions

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verapamil (Calan) and diazepam (Cardizem) have additive hypotensive effects
propranolol use can mask the hypoglycemic effect of insulin and prevent the breakdown of fat in response to hypoglycemia

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divalproex interactions

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aspirin, chlorpromazine, and cimetidine may cause divalproex sodium toxicity
benzodiazipines may cause CNS depression
divalproex may increase levels of phenobarbital and phenytoin

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amitriptyline interactions

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barbiturates may cause increased CNS depression
cimetidine may increase amitriptyline levels
MAOIs may increase CNS excitation or cause seizures
verapamil

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verapamil interactions

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carbamazepine and digoxin may increase medication levels
atenolol, esmolol, propranolol, and timolol may potentiate medication effects

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migraine meds admin

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avoid consumption of alcohol and tyramine-containing foods
protect skin from sun

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migrain meds effectivess

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reduction in intensity and frequency of migraine attacks
prophylaxis against migraine attacks
termination of migraine headaches

Front 41

local anesthetics

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proto: lidocaine (Xylocaine)
other: tetracaine (Pontocaine), procaine (Novocain)

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local anesthetic MOA

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decrease pain by blocking conduction of pain impulses to a circumscribed area

Front 43

local anesthetic uses

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parenteral:pain managment
regional anesthesia

topical: skin and mucous membrane disorders
minor procedures such as IV insertion, injection, wart removal

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local anesthetic adverse

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CNS excitation
hypotension
cardiodepression
allergic reaction
caution to women in labor
spinal headache
urinary retention

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local anesthetic contraindications

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supraventricular dysrhythmias/ heart block
liver, kidney dysfunction, HF, myasenthia gravis
epinepherine added to local anesthetic is contraindicated for use in fingers, nose, and other body parts with end arteries, gangrene may result from vasoconstriction

Front 46

local anesthetic interactions

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antihypertensive meds- monitor heart rate and BP

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local anesthetic effectiveness

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undergoes procedure without experiencing pain
pain is relieved