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26 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Name the nonspecific beta2 agonist
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Isoproterenol
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What is the action of Isoproterenol?
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Relaxes bronchial smooth muscle. Beta2
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What is the adverse effect of Isoproterenol?
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Tachycardia (beta1)
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Name the Beta2 agonists.
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Albuterol
Salmeterol |
Beta2
A S |
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What is the action of beta 2 agonists?
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Albuterol - relaxes bronchial smooth muscle beta 2
Salmeterol - long-acting agent for prophylaxis |
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What drug do you use during acute exacerbation?
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Albuterol
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What are the adverse effects of Salmeterol?
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Arrhythmia
Tremor |
S.A.T.
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Name the methylxanthines.
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Theophylline
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What is the function of Theophylline?
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Causes bronchodilation by inhibiting phosphodiesterase, thereby decreasing cAMP hydrolysis
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What are the adverse effects of theophylline?
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Cardiotoxicity
Neurotoxicity |
T.N.C
Heart and Brain |
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Name the muscarinic antagonists.
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Ipratropium
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What is the function of Ipratropium?
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Competitive block of muscarinic receptors, preventing bronchoconstriction.
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Name the asthma drug used for COPD.
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Muscarinic antagonists
aka Ipratropium |
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MOA Cromolyn
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Prevents release of mediators from mast cells
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Name the asthma drug used for prophylaxis
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Cromolyn
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Name the corticosteroids
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Beclomethasone
Prednisone |
C.B.P.
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What is the function of corticosteroids?
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Inhibit synthesis of cytokines
Inactivate NF-kB |
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What is the function of NF-kB?
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Transcription factor that induces the production of TNF-alpha
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What is the 1st line therapy of chronic asthma?
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Beclomethasone
Prednisone |
Corticosteroids - chronic asthma
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Name the antileukotrienes
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Zilueton
Zafirlukast Montelukast |
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Name the function of Zileuton?
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5-lipoxygenase pathway inhibitor
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What is the function of 5-lipoxygenase?
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An enzyme that converts arachidonic acid to leukotrienes
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What is the function of Zafirlukast and Montelukast?
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Block leukotriene receptors
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Name the asthma drug used for aspirin-induced asthma.
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Zafirlukast
Montelukast |
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Name the drug useful in severe asthmatic exacerbation
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Magnesium
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MOA Mg2+
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inhibition of Ca2+ effect on smooth muscle
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