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51 Cards in this Set
- Front
- Back
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SE LSD
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Hyperreflexia
Nausea M. weakness |
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MOA LSD
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SNS activation - arousal, tachycardia, sweating, mydriasis, HTN, piloerection, fever
LD - brilliant color hallucinations & mood alterations |
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SE THC
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Red conjunctiva
Increased HR Decreased BP Mental & psychiatric Sign. learning potential reduction Anxiety, schiophrenia URI, LRI |
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PCP SE
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Arthralgia
Numbness of extremities Staggered gait Slurred speech M. rigidity Full anesthesia, stupor, coma Bizarre & aggressive behavior |
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SE Ketamine
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Dissociative anesthesia, analgesia, bronchodilation, HTN, increased HR & CO
Hallucinations Ulceration of urinary bladder linning |
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Effects of stimulation of Mu receptor
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Resp. depression
Euphoria/sedation Physical dependence Decreased GI motility Pupil constriction ANALGESIA |
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Effects of stimulation of Kappa R
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Analgesia
Sedation/dysphoria Pupil constriction |
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MOA Opioids
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Stimulate Gi proteins --> inhibiting AC
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MOA Naloxone
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Displaces all R-bound opiate molecules
Reverses OD |
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Use Propoxyphene
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dextro - mild - mod pain
levo - antitussive |
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MOA & use Methadone
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STRONG opioid agonist w/ LONG duration
Used to tx of drug WD from opioids |
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What is special about Heroin
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Crosses the BBB
Extreme euphoria |
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What are the TCAs
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Amitriptyline
Clomipramine Desipramine Imipramine |
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SE TCAs
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Anticholinergic effects
(Xerostomia, C, urinary retention, aggravation of glaucoma, blurred vision, risk of seizures) Reflex tachycardia, orthostatic hypotension |
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Who are TCAs contraindicated in
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Manic-depressive pt
Suicidal pt |
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What are the SSRIs
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Citalopram
Escitalopram Fluoxetine Paroxetine Sertraline |
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SE SSRIs
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Loss of libido
Delayed ejaculation Wt gain Anorgasmia |
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OD SSRIs causes
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Seizures
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Who should avoid use of SSRIs
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Pregnant
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What are the MAOIs
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Phenelzine
Isocarboxazid Tranylcypromine |
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Why can't you use MAOIs & (SSRIs, SNRIs, TCAs) together? How long until you can?
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Risk serotonin syndrome
2 week "wash-out" |
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What foods can you not eat while taking MAOIs?
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High in tyramine content
(cheese, beer, wine, chicken liver) |
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SE MAOIs
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Constipation
Blurred vision Xerostomia Drowsiness Dysuria |
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Who are MAOIs contraindicated in
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People who refuse to stop consuming tyramine
Suicidal pt |
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What are the SNRIs
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Desvenlafaxine
Venlafaxine Duloxetine **Do not use in 3rd trimester |
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SE Bupropion
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Lower seizure threshold
(Does not cause wt gain, sexual dysfunction) Dry mouth, tinnitus, nausea Hallucination & psychosis HTN |
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MOA Lithium
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Interferes w/ normal function of Na
(causing increased elimination of K) Low therapeutic index |
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SE Lithium
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d/t K loss
(m. tremor, ataxia, acquired DI, twitching, seizures) |
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SE Lamotrigine
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Stevens-Johnson syndrome
Toxic epidermal necrolysis Many drug-drug interactions |
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MOA Lamotrigine
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Inhibit voltage-gated Na channels
Weakly block serotonin & sigma opioid R |
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MOA Topiramate
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Enhansed GABA-activated Cl channel
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SE Topiramate
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HA
Paresthesias Increased risk URI Wt loss Renal stones Decrease sweating (risk of hyperthermia) Temporary or permanent blindness |
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MOA Valproic acid
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Increases concentration GABA
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SE Valproic acid
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Thrombocytopenia
GI problems Risk fatal hepatic failure & fatal pancreatitis (many drug-drug interactions) |
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Valproic acid is contraindicated in who
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Liver pt
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SE Carbamazepine
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Stevens-Johnson syndrome
Toxic epidermal necrolysis Migraines Cardiac arrhythmias BM suppression (agranulocytosis & aplastic anemia) Hepatitis Exacerbate hypothyroidism |
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Use of Carbamazepine
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Bipolar d/o
Seizure d/o Phantom limb syndrome ADD/ADHD Trigeminal neuralgia |
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MOA Gabapentin
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GABA analog - no known effect at GABA R
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Methylxanthines at low doses
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Increases alertness
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methylxanthines at high dose
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anxiety
Tremors Positive inotropy & chronotropy |
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MOA methylxanthines
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Sm m relaxants
Weak diuretics (loss of Na, Cl, K) Enhanse HCl secretion in stomach Ca influx & decreased histamine release Inhibit phosphodiesterase & block adenosine R |
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WD symptoms of methylxanthines
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Lethargy
Irritability HA |
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Effects of nicotine at lose dose
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Ganglion stimulator
(increases BP, euphoria, arousal, relaxation, improves attention, learning & problem-solving) |
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Effects of nicotine at high doses
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"binds up all R" blocks them
Decreases BP severely Central respiratory paralysis GI/bladder inactivity |
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SE nicotine
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Irritability
Tremors Intestinal cramps/D Increased HR, BP, metabolism of other drugs |
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WD symptoms of nicotine
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Irritability, anxiety, restlessness, difficulty concentrating, HA, insomnia, increased appetitie, GI paine
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Effects of Cocaine
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Increases mental awareness
Produces feeling of well-being & euphoria Increases motor activity (HD - tremors & convulsions) |
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SE cocaine
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Fatal cardiac arrhythmias
Anxiety w/ HA, tachycardia, sweating, paranoia, depression, HF, seizure |
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WD Cocaine a/w what
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high rate of suicide
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Use amphetamines
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Depression
Hyperactive children Appetite control Narcolepsy |
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SE Amphetamines
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Insomnia, irritability, tremor, hyperactive reflexes, confusion, panic states, suicide, amphetamine psychosis, cardiac arrhythmias, HA, sweating, N/V/D
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