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31 Cards in this Set
- Front
- Back
MOA Bromocriptine
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Dopamine R agonist --> VC
Inhibits prolactin release (adj in tx transplant recipients) |
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Use Bromocriptine
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Parkinson's
Hyperprolactinoma |
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SE Bromocriptine
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Worsens any pre-existing mental conditions
Hallucinaitons, confusion, delirium, N, orthostatic hypotension |
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What enzyme is responsible for
CO2 + H2O <--> H2CO3 <--> H + HCO3 |
Carbonic anhydrase
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MOA carbonic anhydrase inhibitors
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Normally, H exchanged for Na (H out, Na in)
If no H, no Na is going back into cell from lumen |
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Use carbonic anhydrase inhibitor (Acetozolamide)
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Chronic tx open angle glaucoma (uses same H/Na exchanger in aqueous humor production)
Mountain sickness (encourages loss of excess bicarb & decreases CSF fluid) |
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SE CAI
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Hypokalemia
Renal stone formation Drowsiness Metabolic acidosis |
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MOA Loop diuretics
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Inhibit NKCC in ascending loop
(decrease Na, K, Cl reabsorption) Loss of Ca |
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Use loop diuretics
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Decompensated CHF
Edema in those w/ renal dz HTN management in CHF pt |
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SE loop diuretics
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Hypovolemia
Toxicity Hypokalemia Hyperuricemia Alkalosis |
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Furosemide & toresmide: What kind of drugs
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Loop diuretics
|
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Who are loop diuretics contraindicated in?
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Sulfa allergy
|
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MOA thiazides
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Inhibit NCC channel in DCT
(only effective if functional kidneys) Ca reabsorption |
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Use thiazide
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1st line - HTN in all pt except (renal dz, DM, CHF, CAD)
Those others you would use in conjuction with other drugs Urinary Ca stones |
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SE thiazides
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Hypovolemia
Hypercalcemia |
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MOA spironolactone
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Inhibits aldosterone
(inhibit Na reabsorption in late DCT & CD) |
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MOA triamterene & amiloride
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Directly block Na/K exchange in late DCT & CD
|
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Use of potassium sparing diuretics
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HTN (esp. in combo for HTN & severe CHF)
|
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SE Spironolactone
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Hyperkalemia
Lethargy Gynecomastia Menstrual irregularities |
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SE Amiloride or triamterene
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Leg cramps
Hyperkalemia Hyperuricemia High BUN |
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Mannitol & Urea: What kind of drugs are these?
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Osmotic agents
|
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MOA of osmotic agents
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Hydrophilic agents filtered through glomeruli & drag water with them
|
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Use osmotic agents
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Acute RF d/t shock or trauma
Maintain urine flow following toxic ingestion Decrease intracranial P |
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Special about nitroglycerine's metabolism
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Significant 1st pass effect
(given SL for decreased metabolism - longer effect) |
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MOA nitrates
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Potent venodilators (decrease preload)
HD - arterial dilation (decrease afterload) |
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How long does sublingual nitroglycerin work?
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One minute
|
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Contraindications for nitrates
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Hypotension (SBP < 90)
Bradycardia (< 50) Tachycardia (> 100) Right VF Erectile dysfunction therapy w/i past 24-48 hrs |
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Common SE nitrates
|
HA
|
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Special about the metabolism isosorbide dinitrate
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Not readily metabolized by liver
(can give PO) onset - 1 hr |
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Use isosorbide dinitrate
|
chronic maintenance
|
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Use CCB
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Daily antianginal therapy
Prinzmetal's angina |