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31 Cards in this Set

  • Front
  • Back
MOA Bromocriptine
Dopamine R agonist --> VC
Inhibits prolactin release
(adj in tx transplant recipients)
Use Bromocriptine
Parkinson's
Hyperprolactinoma
SE Bromocriptine
Worsens any pre-existing mental conditions
Hallucinaitons, confusion, delirium, N, orthostatic hypotension
What enzyme is responsible for
CO2 + H2O <--> H2CO3 <--> H + HCO3
Carbonic anhydrase
MOA carbonic anhydrase inhibitors
Normally, H exchanged for Na (H out, Na in)
If no H, no Na is going back into cell from lumen
Use carbonic anhydrase inhibitor (Acetozolamide)
Chronic tx open angle glaucoma (uses same H/Na exchanger in aqueous humor production)
Mountain sickness (encourages loss of excess bicarb & decreases CSF fluid)
SE CAI
Hypokalemia
Renal stone formation
Drowsiness
Metabolic acidosis
MOA Loop diuretics
Inhibit NKCC in ascending loop
(decrease Na, K, Cl reabsorption)

Loss of Ca
Use loop diuretics
Decompensated CHF
Edema in those w/ renal dz
HTN management in CHF pt
SE loop diuretics
Hypovolemia
Toxicity
Hypokalemia
Hyperuricemia
Alkalosis
Furosemide & toresmide: What kind of drugs
Loop diuretics
Who are loop diuretics contraindicated in?
Sulfa allergy
MOA thiazides
Inhibit NCC channel in DCT
(only effective if functional kidneys)

Ca reabsorption
Use thiazide
1st line - HTN in all pt except (renal dz, DM, CHF, CAD)

Those others you would use in conjuction with other drugs

Urinary Ca stones
SE thiazides
Hypovolemia
Hypercalcemia
MOA spironolactone
Inhibits aldosterone

(inhibit Na reabsorption in late DCT & CD)
MOA triamterene & amiloride
Directly block Na/K exchange in late DCT & CD
Use of potassium sparing diuretics
HTN (esp. in combo for HTN & severe CHF)
SE Spironolactone
Hyperkalemia
Lethargy
Gynecomastia
Menstrual irregularities
SE Amiloride or triamterene
Leg cramps
Hyperkalemia
Hyperuricemia
High BUN
Mannitol & Urea: What kind of drugs are these?
Osmotic agents
MOA of osmotic agents
Hydrophilic agents filtered through glomeruli & drag water with them
Use osmotic agents
Acute RF d/t shock or trauma
Maintain urine flow following toxic ingestion
Decrease intracranial P
Special about nitroglycerine's metabolism
Significant 1st pass effect
(given SL for decreased metabolism - longer effect)
MOA nitrates
Potent venodilators (decrease preload)
HD - arterial dilation (decrease afterload)
How long does sublingual nitroglycerin work?
One minute
Contraindications for nitrates
Hypotension (SBP < 90)
Bradycardia (< 50)
Tachycardia (> 100)
Right VF
Erectile dysfunction therapy w/i past 24-48 hrs
Common SE nitrates
HA
Special about the metabolism isosorbide dinitrate
Not readily metabolized by liver
(can give PO)
onset - 1 hr
Use isosorbide dinitrate
chronic maintenance
Use CCB
Daily antianginal therapy
Prinzmetal's angina