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6 Cards in this Set
- Front
- Back
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name 2 types of calcification
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dystrophic- in necrotic cells
metastatic- in normal cells with hypercalcemia |
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describe apoptotic activation
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extrinsic
TNF and FAS bind their ligand and receptor trimerizes cleaves to form caspase 8 which activates caspase 3 intrinsic- mitochondria cytochrome c released mitochondrial membrane, forms complex with Apaf-1 and procaspase 9 active caspase 9 cleaves procaspase 3 activates proteases and endonucleases and enzymes that cross-link proteins to allow formation of apoptotic bodies |
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what are the pro-apoptotic proteins? anti?
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pro- Bax, Bcl-Xs, Bad, Bid, Bim, Bak
anti- Bcl-2, Bcl-Xl, Bcl-w |
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what are the chemical mediators and their functions in the clotting cascade?
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Xa- inc vascular permeability and leukocyte emigration
thrombin- enhances leukocyte adhesion and cleaves c5 fibrinopeptides- inc vascular permeability and leukocyte chemotaxis |
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what enzymes metabolize arachidonic acid? what does this lead to?
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cyclooxygenase- prostaglandin synthesis and thromboxanes
lipoxygenase- results in leukotrienes and lipoxins |
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what does PAF do?
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activates platelets, inc vascular permeability and vasodilation (10k x greater than histamine), leukocyte aggregation, chemotaxis, activates other mediators
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