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69 Cards in this Set
- Front
- Back
Pulmonary Circuit
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The flow of blood from the heart through the lungs back to the heart
Picks up oxygen and releases carbon dioxide in the lungs |
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System Circulation:
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The flow of blood from the heart through the body back to the heart
Delivers oxygen and picks up carbon dioxide in the body’s tissues |
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Location, size and shape of the heart
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Location
Anterior to the vertebral column, posterior to the sternum Left of the midline Deep to the second to fifth intercostal spaces Superior surface of diaphragm Shaped like a blunt cone, with an apex and a base Approximately the size of your fist |
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Pericardial Sac that encloses the heart:
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a double-walled sac around the heart composed of
A superficial fibrous pericardium A deep two-layer serous pericardium |
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parietal layer
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lines the internal surface of the fibrous pericardium
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visceral layer
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lines the surface of the heart
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pericardial cavity
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Parietal and Visceral layer are separated by the fluid-filled (pericardial fluid)
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Three Layers of the Heart Wall:
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Epicardium
Myocardium Endocardium |
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Epicardium
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Visceral layer of the serous pericardium (visceral pericardium)
Provides protection against the friction of rubbing organs |
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Myocardium
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Cardiac muscle layer forming the bulk of the heart
Responsible for contraction |
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Endocardium
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Endothelial layer over crisscrossing, interlacing layer of connective tissue
Inner endocardium reduces the friction resulting from the passage of blood through the heart |
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4 chambers of the heart:
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The two ventricles (right and left) are muscular chambers that propel the blood out of the heart (the right ventricle to the lungs, and the left ventricle to all other organs).
The two atria (right and left) hold the blood returning to the heart, and at just the right moment empty into the right and left ventricles. |
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Atrioventricular (AV) valves
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lie between the atria and the ventricles
AV valves prevent backflow into the atria when ventricles contract |
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Chordae tendineae
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anchor AV valves to papillary muscles
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Tricuspid valve:
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separates the right atrium and ventricle
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Bicuspid valve:
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separates the left atrium and ventricle
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Semilunar valves do what?
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prevent backflow of blood into the ventricles
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Two types of semilunar valves:
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Aortic semilunar valve: lies between the left ventricle and the aorta
Pulmonary semilunar valve: lies between the right ventricle and pulmonary trunk |
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Route of Blood Flow through the heart: Blood from the body....
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flows through the right atrium into the right ventricle and then to the lungs
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Route of Blood Flow from the lungs....
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Blood returns from the lungs to the left atrium, enters the left ventricle, and is pumped back to the body
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Coronary arteries
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branch off the aorta to supply the heart
Blood returns from the heart tissues to the right atrium through coronary sinus and cardiac veins |
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Fibrous Skeleton of the Heart
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Consists of a plate of fibrous connective tissue
Forms fibrous rings around the AV and SL valves for support Provides a point of attachment for heart muscle Electrically insulates the atria from the ventricles |
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Cardiac Muscle Cells
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Are branched and have a centrally located nucleus
Actin and myosin are organized to form sarcomeres (striated) T tubules and sarcoplasmic reticulum are not as organized as in skeletal muscle Normal contraction depends on extracellular Ca2+ Rely on aerobic respiration for ATP production They have many mitochondria and are well supplied with blood vessels Joined by intercalated disks Allow action potentials to move from one cell to the next, thus cardiac muscle cells function as a unit |
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Action Potentials
(electrical activity of the heart) |
After depolarization and partial repolarization, a plateau phase is reached, during which the membrane potential only slowly repolarizes
The opening and closing of voltage-gated ion channels produce the action potential |
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depolarization
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The movement of Na+ through Na+ channels
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During depolarization
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K+ channels close and Ca2+ channels begin to open
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Early repolarization results from ...
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closure of the Na+ channels and the opening of some K+ channels
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The plateau exists because ...
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Ca2+ channels remain open
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The rapid phase of repolarization results from
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the closure of the Ca2+ channels and the opening of many K+ channels
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2 Refractory Periods :
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Absolute refractory period
Cardiac muscle cells are insensitive to further stimulation Relative refractory period Stronger than normal stimulation can produce an action potential |
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Why do cardiac muscles relax before AP causes a contraction?
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Cardiac muscle has a prolonged depolarization and thus a prolonged absolute refractory period
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Some cardiac muscle cells are autorhythmic because ...
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spontaneous development of a prepotential
Prepotential: slowly developing local action potential |
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sinoatrial (SA) node is...
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pacemaker of the heart
Collection of cardiac muscle cells capable of spontaneously generating action potentials |
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Heart rate is determined by...
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duration of the prepotential
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Prepotential:
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slowly developing local action potential
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The sinoatrial (SA) node and the atrioventricular (AV) node are in
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The RIGHT atrium
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The AV node is connected to
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the bundle branches in the interventricular septum by the AV bundle
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Purkinje fibers:
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supply the ventricles and carry the impulse to the heart apex and ventricular walls
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What does the SA node initiate?
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Action potentials that spread across the atria and cause contraction
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Where do the Action potentials slow down?
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AV node. This allows atria to contract and blood to flow into the ventricles
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atrioventricular bundles
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pass the action potentials from atria to ventricles
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Where do the AV bundle splits into two pathways ?
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interventricular septum
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P wave
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corresponds to depolarization of the atria (SA node)
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QRS complex
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corresponds to ventricular depolarization
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T wave
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corresponds to ventricular repolarization
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Atrial repolarization record is masked by the...
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QRS complex
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ECGs can be used to diagnose
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heart abnormailities
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Atrial systole
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contraction of the atria
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Systole
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contraction of the ventricles
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Atrial diastole
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relaxation of the atria
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Diastole
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relaxation of the ventricles
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During systole ( 4 things happen)
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AV valves close
Pressure increases in the ventricles Semilunar valves are forced to open Blood flows into the aorta and pulmonary trunk |
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At the beginning of diastole (2 things happen)
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Pressure in the ventricles decreases
Semilunar valves close to prevent backflow of blood from the aorta and pulmonary trunk into the ventricles |
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When the pressure in the ventricles is lower than in the atria
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the AV valves open and blood flows from the atria into the ventricles
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During atrial systole
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the atria contract and complete the filling of the ventricles
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3 Events Occurring During Ventricular Systole
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1. Ventricular depolarization
2.The volume of blood in a ventricle just before it contracts is the end- diastolic volume 3.The volume of blood after contraction is the end- systolic volume |
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Ventricular depolarization produces:
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the QRS complex
Initiates contraction of the ventricles, which increases ventricular pressure The AV valves close Semilunar valves open Blood is ejected from the heart |
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Aortic Pressure Curve
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Contraction of the ventricles forces blood into the aorta
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systolic pressure is
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Maximum pressure in the aorta
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diastolic pressure is
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Minimum pressure in the aorta
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Heart sounds (lub-dup) are associated with :
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First sound occurs as AV valves close and signifies beginning of systole (lub)
Second sound occurs when SL valves close at the beginning of ventricular diastole (dup) |
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Mean arterial pressure is
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the average blood pressure in the aorta
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Cardiac output (CO) is
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product of heart rate (HR) and stroke volume (SV)
HR is the number of heart beats per minute SV is the amount of blood pumped out by a ventricle with each beat |
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Venous return is
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the amount of blood returning to the heart
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Starling’s law
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describes the relationship between preload and the stroke volume of the heart
An increased preload causes the cardiac muscle fibers to contract with a greater force and produce a greater stroke volume |
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LaPlace Law
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Force=Diameter * Pressure (anurism)
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Pousilles law
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velocity of a liquid flowing through a capillary is directly proportional to the pressure of the liquid (viscosity as well included)
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Ischemia (caused by low CO)
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Inadequate blood flow that fails to meet the oxygen demands of tissues
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4 Factors that govern CO:
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1-preload (volume)
2-Afterload (BP) 3-Cardiac Contractility 4-Pulse rate |