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123 Cards in this Set

  • Front
  • Back

Hierarchy of human complexity (8 levels in order)

Atoms --> molecules --> organelles --> cells --> tissues --> organs --> organ systems --> organism

Characteristics of life (8)

1. Maintaining boundaries


2. Movement


3. Responsiveness


4. Digestion


5. Metabolism


6. Excretion


7. Reproduction


8. Growth

Metabolism

Sum total of all chemical reactions that occur in the body.

Homeostasis (and control mechanisms)

Relatively stable internal conditions.



Controlled by negative feedback mechanisms (most common) or positive feedback mechanisms.

3 planes of the body

1. Sagittal plane - vertical plane that divides the body into right and left parts.


2. Transverse/Horizontal plane - runs horizontally from right to left dividing the body into superior and inferior parts.


3. Frontal plane - vertical plane dividing the body into anterior and posterior parts.

Superior vs. Inferior

Superior (cranial) - toward the head end or upper part of the body



Inferior (caudal) - away from the head end or toward the lower part of the body

Anterior vs. Posterior

Anterior (ventral) - toward the front of the body



Posterior (dorsal) - toward the back of the body

Medial vs. Lateral vs. Intermediate

Medial - toward the midline of the body



Lateral - away from the midline of the body



Intermediate - between a more medial and a more lateral structure

Proximal vs. Distal

Proximal - closer to the origin of the body part or the point of attachment of a limb to the body trunk



Distal - farther from the origin of a body part or the point of attachment of a limb to the body trunk

Superficial (external) vs. deep (internal)

Superficial (external) - toward or at the body surface



Deep (internal) - away from the body surface more internal

The diaphragm separates what two body cavities?

Thoracic cavity and abdominal cavity

What is the smallest part of an element?

Atom

What are the parts of an atom?

Nucleus - contains protons and neutrons and is positively charged


Protons - positive charge, 1 atomic mass unit


Neutrons - neutral charge, 1 atomic mass unit


Electrons - negative charge, 0 atomic mass unit


Atomic number

Equal to the number of protons in an atom's nucleus

Mass number

The sum of the masses of an atom's protons and neutrons

Isotopes

Variations of elements in which there are the same number of protons and electrons but different numbers of neutrons.

Atomic weight

An average of the relative weights or mass numbers of all the Isotopes of an element

Electron shells

The region of space around a nucleus where electrons are. There are 7 possible shells numbered 1 to 7 from the nucleus outward.

Octet rule or the rule of eights

Atoms tend to have eight chemically reactive electrons in their outermost valence shell.

Ionic bond

Involves a transfer of electrons

Covalent bond

Involves a sharing of electrons

Anion vs Cation

During the forming of an ionic bond the atom that gains electrons acquires a negative charge and is called an anion. The atom that loses electrons gains a positive charge and is called a cation.

Polar covalent bond vs. Nonpolar covalent bond

A polar covalent bond has unequal sharing of electrons and a slight negative charge at one end of a molecule and a slight positive charge at the other end. A nonpolar covalent bond has equal sharing of electrons and a balanced charge among atoms.

Molecular weight

The sum of the atomic weights in a molecule

Hydrogen bond

A weak intermolecular attraction between a slightly positive hydrogen atom in one molecule and a slightly negative oxygen or nitrogen in another.

Characteristics of water (6)

1. 50-75% of the body is water


2. Solvency - most substances dissolve in water


3. Cohesion - water molecules "stick" to each other.


4. Adhesion - water "sticks" to other substances.


5. Chemical reactivity - water is important in dehydration synthesis and hydrolysis reactions


6. Thermal stability - water gains and loses heat very slowly.

Solutions

Homogenous mixture of components. Has two parts: solvent (substance present in greatest amount) and solute (substance being dissolved/substance present in smaller amounts).

Colloids

Heterogeneous mixtures who solutes do not settle out

Suspensions

Heterogeneous mixtures with visible solutes that tend to settle out

Anabolism

Synthesis

Catabolism

Decomposition

Carbohydrates

AKA sugars. Includes monosaccharides, disaccharides, and polysaccharides. Most important is glucose which is the body's readily available source of energy. It is stored as glycogen in the liver and skeletal muscles.

Lipids

AKA fats. Includes triglycerides, phospholipids, and steroids. Lipids are hydrophobic.

Amino acids

The building blocks of protein

Structural levels of protein

Primary - amino acid sequence Secondary - alpha helices or beta pleated sheets Tertiary - superimposed folding of secondary structures Quaternary - polypeptide chains linked together in a specific manner

Protein denaturation

When a protein loses its 3D shape. Reversible denaturation is caused by drops in PH and/or increased temperature. Irreversible denaturation is caused by extreme pH or temperature changes.

Enzymes

Enzymes help speed up chemical reactions by putting pieces close enough together for a reaction to happen.

Phospholipid bilayer

Part of the plasma membrane. Includes:


Phosphate heads: polar and hydrophilic


Fatty acid tails: nonpolar and hydrophobic

Functions of membrane proteins (6)

1. Transport - cells use proteins to bring substances in and for excreting substances from the cell


2. Receptors of signal transduction - these proteins represent the starting point of intracellular messaging


3. Attachment to cytoskeleton and extracellular matrix - anchoring proteins


4. Enzymatic activity - these proteins increase the rate of chemical reactions


5. Intercellular joining - creation of tissues


6. Cell-to-cell recognition - used by the immune system to recognize foreign pathogens

Glycocalyx

Sugar layer around cells that tell your immune system that this cell is yours and it should not attack.

Microvilli

Finger-like projections that serve to increase the surface area of cells.

Cilia

Hairs on cell surface

Flagella

Tails of cells

5 main cell types in bone

1. Osteogenic cells (stem cells)


2. Osteoblasts (bone builders)


3. Osteocytes (embedded in lacunae)


4. Osteoclasts (break down bone)


5. Bone lining cells

Ossification (two types)

1. Endochondral ossification (begins with hyaline cartilage at the ends of long bones)


2. Intermembranous ossification ( begins with mesenchymal cells, usually forms flat bones)

Parts of a long bone (8 parts)

1. Diaphysis: shaft


2. Endosteum: inside lining


3. Epiphyseal plate: growth plate


4. Epiphysis: ends of long bones


5. Periosteum: covering


6. Red marrow: blood cell production


7. Yellow marrow: fat

Two types of bone growth

Interstitial growth: grows and repairs from the inside


Appositional growth: grows and repairs from the outside

What is the primary mineral found in bone?

Calcium

What are three things involved in calcium homeostasis?

1. calcitriol (vitamin D)


2. parathyroid hormone (increases calcium in the bloodstream)


3. calcitonin (decreases calcium in the bloodstream)

What are the three parts of the axial skeleton?

1. Skull


2. vertebral column


3. rib cage

What are the four components of the appendicular skeleton?

1. Pectoral girdle


2. Upper Limb


3. pelvic girdle


4. lower limb

Bone marking: Projections

Bone markings that bulge outward from the surface. E.g. heads, trochanter, spines, Etc.

Bone markings: Depressions and Openings

Fossae, sinuses, foramina and grooves

Fontanelles

Membranous areas between cranial bones. Include the anterior fontanelle, the posterior fontanelle, the sphenoidal fontanelle, and mastoid fontanel.

Intervertebral disc

Made of fibrocartilage. Cushionlike pad between the vertebra.

Joint classifications by degree of movement: fibrous joints

1. Syndesmosis - found at the distal end of the tibia, fibula, ulna, and radius


2. Gomphosis - articulation between the teeth and the jaw


3. Sutures - skull bones

Joint classification by degree of movement: cartilaginous joints

1. Synchondrosis: ribs, growth plates


2. Symphysis: intervertebral discs fibrocartilage

Joint classification by degree of movement

1. Synarthrosis- immovable


2. Amphiarthrosis - slightly movable


3. Diarthrosis - freely movable

Synovial joint

Synovial joints have a fluid-filled joint cavity. E.g. hinge joint (elbow), pivot (head), ball-and-socket (hip or shoulder)

Types of lever systems

1. First class (e.g. seesaw)


2. Second class (e.g. wheelbarrow)


3. Third class (e.g. tweezers)

5 functional characteristics of muscles

1. Responsiveness


2. Conductivity


3. Contractility (no other tissue has this)


4. Extensibility


5. Elasticity

What are the ends of muscles called?

The immovable end is called the origin. The movable end is called the insertion.

Sarcomere

Structural unit of muscle.



Components:


1. Sarcolemma: muscle cell membrane


2. Sarcoplasmic reticulum: stores calcium


3. Myofibrils: myosin (thick) and actin (thin)


4. T tubules


5. Glycosomes


6. Myoglobin

Regulatory proteins

1. Tropomyosin (blockade over binding site)


2. Troponin (key to unlock the lock)

Power stroke

Myosin attaches to actin molecules and muscle moves

Three types of muscle attachments

1. Direct muscle attachment (e.g. ribs)


2. Indirect muscle attachment (most common, connect with tendons)


3. Aponeurosis (sheet of tendons)

Muscle types by fascicular arrangement

1. Fusiform


2. Parallel


3. Convergent


4. Pennate - feather like


5. Circular

Muscle classification: functional groups

1. Prime movers -Agonists: primarily responsible for producing movement


2. Synergists: help


3. Antagonists: oppose


4. Fixators: stabilize

What is a tendon?

A cord like extension of muscle

7 Ways muscles are named

1. Muscle location (e.g. temporalis)


2. Muscle shape (e.g. deltoid or trapezius)


3. Muscle size (e.g. gluteus maximus)


4. Directions of muscle fibers (e.g. erectus abdominus or transversus abdominis)


5. Number of Origins (e.g. biceps brachii)


6. Location of the attachments (e.g. sternocleidomastoid)


7. Muscle action (e.g. adductor longus)

Nervous system functions

1. Sensory input (stimulus receptors for pain, pressure, temperature)


2. Integration


3. Motor output

Functional classification of neurons

1. Sensory (afferent)


2. Interneurons (association)


3. Motor (efferent)

Structural classification of neurons

1. Multipolar neurons (99% of all neurons)


2. bipolar neurons (rare, found in special senses)


3. unipolar neurons (sensory neurons)

Two types of neuron processes

1. Dendrites (incoming)


2. Axons (outgoing)

What does a synaptic vesicle do?

Holds neurotransmitters

Resting membrane potential (polarization)

The inside of the cell membrane is more negatively charged than the outside

Depolarization

A decrease in membrane potential: the inside of the membrane becomes less negative than the resting potential.

Hyperpolarization

An increase in membrane potential: the inside of the membrane becomes more negative than the resting potential.

Myelin sheath

Increases the transmission speed of nerve impulses. Formed in the PNS by Schwann cells and in the CNS by oligodendrocytes.

Four types of neuroglial cells

1. Astrocytes: most numerous make blood-brain barrier


2. oligodendrocytes: make myelin in CNS


3. ependymal cells: line the ventricles


4. microglia: phagocytes

What is the absolute refractory period?

The period when a neuron cannot respond to another stimulus.

Two types of postsynaptic potentials

1. Excitatory Postsynaptic Potentials (EPSP) - depolarization


2. Inhibitory Postsynaptic Potential (IPSP) - hyperpolarization

Where is cerebrospinal fluid formed and reabsorbed?

It is formed in the choroid plexus and reabsorbed in the arachnoid Villi

Gyri

Elevation

Sulci

Depression

Fissure

Deep grooves

What is the function of the corpus callosum?

Connects hemispheres so they can operate as a coordinated whole.

Five lobes of the cerebrum and their basic functions

1. Temporal: hearing


2. frontal: personality and motor output


3. parietal: sensory input


4. occipital: Vision


5. insula

What is the function of the thalamus?

It relays incoming sensory information

What is the purpose of the hypothalamus?

It regulates hunger, temperature, sexual response, thirst, etc.

What is the cerebellum involved in?

Motor coordination

What are the three parts of the midbrain?

1. Corpora quadrigemina


2. red nucleus


3. substantia nigra

What is the medulla oblongata for?

It's the decussation center where incoming afferent pathways cross. It controls heart rate, blood pressure, and respiratory rate

Name the meninges in order from superficial to Deep

Dura mater, epidural space, arachnoid Mater, subarachnoid space, Pia Mater

Regions of the spine in order from top to bottom

Cervical enlargement, lumbar enlargement, conus medullaris, cauda equina, filum terminale

Spinal tracts

Ascending (sensory) tracts are three neuron chains going up.



Descending motor tracts are two neuron chains going down.

How are gray and white matter arranged in the spinal

Gray matter is on the inside and forms horns and the gray commisure.



White matter is on the outside and it forms columns.

What is the breakdown of spinal nerves?

8 cervical


12 thoracic


5 lumbar


5 sacral


1 coccygeal

What are the two roots of spinal nerves and their purpose?

Dorsal root: sensory information in


Ventral root: motor output

Name the four major nerve plexuses and the primary nerve in each

1. Cervical plexus - phrenic nerve


2. brachial plexus - arm


3. Lumbar plexus- femoral


4. sacral plexus - sciatic

What is a nocireceptor?

Pain receptor

What is a chemoreceptor?

Detect changes in glucose, oxygen, and hydrogen ion concentration.

What do Merkel discs detect?

Light touch

What do meissner corpuscles detect?

Light pressure

What do lamellar corpuscles detect?

Deep pressure

What are the effectors of the autonomic nervous system?

It controls the heart, smooth muscles, and glands.

What is the sympathetic division known for?

Fight or flight

What is the parasympathetic division known for?

Resting and digesting

What are cholinergic fibers?

Axon terminals that release acetylcholine.

What are adrenergic fibers?

Axon terminals that release norepinephrine.

What are cholinergic receptors?

Acetylcholine binds to them

What are adrenergic receptors?

Norepinephrine binds to them

What are the primary receptors for taste (gustation)?

Taste hairs

The primary receptors for smell (olfaction)?

Olfactory cells which are bipolar neuron receptors

Where are the primary receptors for hearing?

Cochlea

What picks up sensory hearing input?

Temporal lobe

What is the vestibular apparatus?

The collective term for equilibrium receptors.

What is the Crista ampullaris?

Dynamic equilibrium receptor

What is the macula?

Static equilibrium receptor

What are the three layers of the eye and what is located in each?

Fibrous layer: (outer layer) includes sclera and cornea


Vascular layer: this is where the blood supply is. Includes choroid, ciliary body and Iris


Inner layer: retina

What is the aqueous humor?

The anterior segment of the eye

What is the vitreous body or vitreous humor?

The posterior segment of the eye

What are the two types of photoreceptors and what do they see?

Rods: black and white receptors, give vision in dim light


Cones: color receptors, they require lots of light