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23 Cards in this Set

  • Front
  • Back
What are the classifications of anxiety disorders?
GAD, panic, agongaphobia, OCD, phobic, acute, PTSD
What is the structural pathophysiology of anxiety?
hypothalamus - initiate fight of flight response via CRF
release NE, activates peripheral SNS
amygdala- center of body's fear response
hippocampus- coordinates memories from multiple sensory inputs
HORMONAL- Cortisol
What is the neurological pathophysiology of anxiety?
serotonin- inhibitatory HP A and locus ceruleus
GABA acid
Dopamine - reward in brain
epi/norepi
What is the tx of free floating anxiety?
excess worry for more than 6 months
BZDs, psychotherapy and anticonvulsants
What is the tx for panic disorder?
4 attack within 4 weeks
BZDs, TCA's, SSRIs
MOAIS and behavior techniques
how do you treat phobic disorders?
beta blockers
MAOIs or SSRIs
How do you treat OCD?
clomipramine
SSRi
behavorial therapy
How do you treat ASD?
bZD
How do you treat PTSD?
SSRI
BZD
act at GABA and BZD receptor
short term use
psysiologic dependencty after 4 weeks and need to taper
Buspirone
partial agonist of 5HT1 receptor
requires multiple daily doses
n/dizziness & somnolence
SSRIs
paroxetine - most sedating
fluoxetine - anxiety worse than better
for OCD and panic disorder and GAD
3-6 weeks to work
Tricyclic Antidepressants
imipramine
clomipramine
depression/anxiety and panic disorder
limit because of AE
MAOIs
panic disorder atypcial refractory depression
block breakdown of serotonin and NE
no tyramine
DDI with narcotics
Non SSRIs
effects conc of serotonin +/-
mirtazapine anxiety but cause wt gain
bupropion
venlafaxine
Antihistimines
hydroxyzine
AE- sedation, decreased cognition, anticholnergic SE's
useful with substance abuse and itch related anxiety
Anticonvulsants
augmentation therapy
tiagabine
gabapentin- enhance GABA
Valproate, lamotrigine, topiramate
Non pharmacologic therapy
avoid caffiene
psychotherapy
reduce unnecessary stress
OCD
fluxetine
fluvoxamine
sertraline
parosetine
venlafaxine
Panic
fluxetine
sertraline
parosetine
Social anxiety
parosetine
venlafaxine
GAD
parosetine
venlafaxine
PTSD
parosetine