Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/43

Click to flip

43 Cards in this Set

  • Front
  • Back
What should the dose of drug that inhibits virus replication be?
low
what should dose of drug that is toxic be?
high
Which 2 drugs were found via blind screening?
amantadine, acyclovir
which was found by mech based screening? (1)
Nevirapine
What was determined by structure/computer based screening?
influneza A NA
Pleconaril-virus/step
rhinovirus, attachment/entry, can't bind to ICAM, canyon
amantadine
influenza A uncaoting, prevents M2 binding, acidification fo endosome,
fuzeon T-20-virus
HIV-1 fusion to gp41, binds HR1, preventing interaction w/ HR2
rimantadine (derivative of what)
amantadine, influenza A prevents M2, endosome acidfication
DNJ-2 viruses
inhibits glycusodiase, HBV, HCV
acyclovir (2)
HSV, ZSV, nucleoside inhibitor,
acyclovir (2)-imitaites what
deoxyguanosine
famcicylovir -derivative of what?
acyclovir-HSV, ZSV, nucleotide inhibitor
valacylcovir-derivatve of what?
acyclovir-ZSV, HSV, nculeotide inhibitor
AZT
HIV-1 RT, nucleotsie imitator,
AZT-imitates what
thymidine
2' C methylcytidine
HCV, flvavirius , nucleoside inhibitor -
NM283 -derivatve of what
2'C methylcytidine, prodrug
Stavudine-dericvative of ?
thymidine, nucleoisde inhibitor
Nevirapine
HIV-1 RT, non nucleotide inhibitor
rescriptor
HIV-1 RT, non nucleotide inhibitor
Sustiva
HIV-1 RT, non nucleotide inhibitor
Foscarnet (3)
HSV DNA pol, non nucleotide inhibitor, HIV RT, Hep B pol
MK 0158
HIV integrase inhibitor, non nucleotide
GS9137
HIV integrase inibitor, non nucleotide
Ritonavir
HIV protease PRO/RT
Squinivir
HIV protease MA/CA
Darunavir
protease
Indinvair
protease
Zanamivir
neuraminase inhibitor (release), influenza A
Ostelamivir
release, influenza A neuraminase
Zanamivir-powder or oral
powder, bad for asthma/lung
Ostelamivir-powder or oral
oral , bad for stomach, headache, diarrhea
Peramivir (5)
influenza neuroaminase, HBV, HCV, polio, measles
Peramivir -inhaled/oral
oral
Ribavirin-tons of stuff-resmebles what?
adenosine, guanosine
Ribavirin-tons of viruses-inhibits? what step
release, IMPDH, inhibiting GMP, RdRp, virion production
side effects Ribavrirn
hemoltyic anemia
viramidine
derivative of ribavirin, not so much trapped ine rythrocytes, inhibits release
which drug is phosphorylated by all cellular TK?
valacyclocvir
which drug has HSV/ZSV TK first then all cellular TK?
acyclovir
48 h before taken, how many days saved?
1 day
30 hours before taken, how many days saved?
3 days