Antivirals

Front 1

What should the dose of drug that inhibits virus replication be?

Back 1

low

Front 2

what should dose of drug that is toxic be?

Back 2

high

Front 3

Which 2 drugs were found via blind screening?

Back 3

amantadine, acyclovir

Front 4

which was found by mech based screening? (1)

Back 4

Nevirapine

Front 5

What was determined by structure/computer based screening?

Back 5

influneza A NA

Front 6

Pleconaril-virus/step

Back 6

rhinovirus, attachment/entry, can't bind to ICAM, canyon

Front 7

amantadine

Back 7

influenza A uncaoting, prevents M2 binding, acidification fo endosome,

Front 8

fuzeon T-20-virus

Back 8

HIV-1 fusion to gp41, binds HR1, preventing interaction w/ HR2

Front 9

rimantadine (derivative of what)

Back 9

amantadine, influenza A prevents M2, endosome acidfication

Front 10

DNJ-2 viruses

Back 10

inhibits glycusodiase, HBV, HCV

Front 11

acyclovir (2)

Back 11

HSV, ZSV, nucleoside inhibitor,

Front 12

acyclovir (2)-imitaites what

Back 12

deoxyguanosine

Front 13

famcicylovir -derivative of what?

Back 13

acyclovir-HSV, ZSV, nucleotide inhibitor

Front 14

valacylcovir-derivatve of what?

Back 14

acyclovir-ZSV, HSV, nculeotide inhibitor

Front 15

AZT

Back 15

HIV-1 RT, nucleotsie imitator,

Front 16

AZT-imitates what

Back 16

thymidine

Front 17

2' C methylcytidine

Back 17

HCV, flvavirius , nucleoside inhibitor -

Front 18

NM283 -derivatve of what

Back 18

2'C methylcytidine, prodrug

Front 19

Stavudine-dericvative of ?

Back 19

thymidine, nucleoisde inhibitor

Front 20

Nevirapine

Back 20

HIV-1 RT, non nucleotide inhibitor

Front 21

rescriptor

Back 21

HIV-1 RT, non nucleotide inhibitor

Front 22

Sustiva

Back 22

HIV-1 RT, non nucleotide inhibitor

Front 23

Foscarnet (3)

Back 23

HSV DNA pol, non nucleotide inhibitor, HIV RT, Hep B pol

Front 24

MK 0158

Back 24

HIV integrase inhibitor, non nucleotide

Front 25

GS9137

Back 25

HIV integrase inibitor, non nucleotide

Front 26

Ritonavir

Back 26

HIV protease PRO/RT

Front 27

Squinivir

Back 27

HIV protease MA/CA

Front 28

Darunavir

Back 28

protease

Front 29

Indinvair

Back 29

protease

Front 30

Zanamivir

Back 30

neuraminase inhibitor (release), influenza A

Front 31

Ostelamivir

Back 31

release, influenza A neuraminase

Front 32

Zanamivir-powder or oral

Back 32

powder, bad for asthma/lung

Front 33

Ostelamivir-powder or oral

Back 33

oral , bad for stomach, headache, diarrhea

Front 34

Peramivir (5)

Back 34

influenza neuroaminase, HBV, HCV, polio, measles

Front 35

Peramivir -inhaled/oral

Back 35

oral

Front 36

Ribavirin-tons of stuff-resmebles what?

Back 36

adenosine, guanosine

Front 37

Ribavirin-tons of viruses-inhibits? what step

Back 37

release, IMPDH, inhibiting GMP, RdRp, virion production

Front 38

side effects Ribavrirn

Back 38

hemoltyic anemia

Front 39

viramidine

Back 39

derivative of ribavirin, not so much trapped ine rythrocytes, inhibits release

Front 40

which drug is phosphorylated by all cellular TK?

Back 40

valacyclocvir

Front 41

which drug has HSV/ZSV TK first then all cellular TK?

Back 41

acyclovir

Front 42

48 h before taken, how many days saved?

Back 42

1 day

Front 43

30 hours before taken, how many days saved?

Back 43

3 days