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16 Cards in this Set

  • Front
  • Back
only herpes viruses
Genital herpes (HSV-2) supressed not cured
Not effective against Active CMV
Renal clearance
Less resistant than Acyclovir
Herpes viruses esp. CMV
Most serious and frequent side effect is bone marrow suppression
phosphorylated by cellular, not viral, enzymes
1/4 patients must withdraw due to nephrotoxicity, ocular hypotony, neutropenia, and metabolic acidosis
inhibits viral DNA pol and RT
NO resistance

Clinical use: CMV retinitis, Acyclovir resistant HSV, Ganciclovir resistant CMV

Side effects: nephrotoxicity, hypocalcemia
HIV Treatments
Nucleoside analogs: Zidovudine, Lamivudine

non-nucleoside RT inhibitors: Nevirapine

Nucleotide analog RT inhibitor: Tenofovir

Peptide analgos that inhibit protease: Ritonavir and Indinavir

Fusion inhibitor: Enfuvirtide
Zidovudine (AZT)
Mechanism: Z-triphosphate binds viral RT, used in combo with RT inhibitor or PI

Clinical Use: HIV-1

Side Effects: most serious and frequent is granulocytopenia and anemia, increased risk of bone marrow toxicity by Amphotericin B
Didanosine (ddI)
Mechanism: if Zidovudine is like TTP, ddI is like ATP
inhibits viral RT

Clinical Use: used in those who can't tolerate Zidovudine or show deterioration with it

Side Effects: peripheral neuropathy and pancreatitis
combo therapy with Zidovudine
GI distress and neutropenia like Zidovudine but less frequent

HIV and chronic treatment of Hep B
non-nucleoside RT inhibitor
nucleotide analag RT inhibitor
prodrugs of AMP analof
Fanconi's syndrome like tetracycline
Dosed 1/day, doesn't require phosphorylation, and anti-hep B activity
Protease inhibitor

Contraindicated with anti-arrhythmics, sedative/hypnotics bc of cyt p450 induction
Side Effects: Worst in the group, GI distress, circumoral paresthesia, increased liver enzymes and CK

*Slows disease progression and reduced mortality
Protease Inhibitor
also reacs with cytP450 (but less so)
Side Effects: Nephrolithiasis
Indinavir+Lamivudine had undetectable levels of virus
Fusion inhibitor
blocks change in gp41
high incidence of local reaction (98%)
Mechanism unknown
ONLY Influenza A
Prophylaxis during epidemics
used in Parkinson's
not metabolized
CNS toxicity
analog of Amantadine
hepatic rather than renal excretion
less CNS toxicity
Oral Neuraminidase inhibitors
Acute Influenza A AND B

Oselt: nausea, headache
Zana: bronchospasm