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7 Cards in this Set

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principal of antiviral therapy
recognize that these should be used best prophalactically instead of used after the fact when the viral mode has reached critical mass
how best used
What are the 3 uses of antiviral drugs?
1. Respiratory Infxn
2. Herpes virus Infxns
3. AIDS
RAH! RAH! I GOT AN INFXN!
amantadine--rimantadine
influenza
some question how working but believed that it prevents virus attaching to the cells. Administered orally
Respiratory Infections
acyclovir
inactivation of dna polymerase which leads to a decrease in replication of the virus. Notably it is only active when the virus is replicating and not when in a dormant stage.
Herpes virus Infections
zidovudine (AZT)
none of these are curative but are able to slow the progression of the HIV infection. Most famous is azt. MOA: interference with reverse transcriptase. HIV is a retrovirus so it uses RNA as its delivery system. Turned in the dna by transcriptase. Ultimately results in a decrease of the reproduction of the virus. You do see resistance to azt, appears to be based on the development of alternative forms of reverse transcriptase. Can see resistance develop overtime in long term use. Adverse: toxic to bone marrow & causes anemia as a result.
AIDS
Didanosine
MOA: ?? appears to be incorporated into dna and prevents replication
used for azt resistance strains of the HIV virus
Zalcitabine
MOA is the same as didanosine
Used as an alternative to azt