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7 Cards in this Set
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- 3rd side (hint)
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principal of antiviral therapy
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recognize that these should be used best prophalactically instead of used after the fact when the viral mode has reached critical mass
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how best used
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What are the 3 uses of antiviral drugs?
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1. Respiratory Infxn
2. Herpes virus Infxns 3. AIDS |
RAH! RAH! I GOT AN INFXN!
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amantadine--rimantadine
influenza |
some question how working but believed that it prevents virus attaching to the cells. Administered orally
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Respiratory Infections
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acyclovir
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inactivation of dna polymerase which leads to a decrease in replication of the virus. Notably it is only active when the virus is replicating and not when in a dormant stage.
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Herpes virus Infections
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zidovudine (AZT)
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none of these are curative but are able to slow the progression of the HIV infection. Most famous is azt. MOA: interference with reverse transcriptase. HIV is a retrovirus so it uses RNA as its delivery system. Turned in the dna by transcriptase. Ultimately results in a decrease of the reproduction of the virus. You do see resistance to azt, appears to be based on the development of alternative forms of reverse transcriptase. Can see resistance develop overtime in long term use. Adverse: toxic to bone marrow & causes anemia as a result.
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AIDS
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Didanosine
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MOA: ?? appears to be incorporated into dna and prevents replication
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used for azt resistance strains of the HIV virus
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Zalcitabine
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MOA is the same as didanosine
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Used as an alternative to azt
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