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13 Cards in this Set
- Front
- Back
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What drugs treat Herpes infections?
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Acyclovir, Valacyclovir, Famciclovir, Gangciclovir, Cidofovir and Foscarnet
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Acyclovir, Valacyclovir, and Famciclovir
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Guanine analogues with no intact sugar residue
Require viral thymidine kinase to add first phosphate Result in chain termination |
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Cidofovir
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Cytosine Analogue with no intact sugar residue
Does not require viral thymidine kinase so good for acyclovir resistant strains Nephrotoxic |
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Foscarnet
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Complexes with DNA Pol to prevent removal of Pyrophosphates so that sugars can't connect
Nephrotoxic |
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Ribavirin
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Normal sugar but guanine base is altered
Incorporating nonsensical base leads no nonsense mrna |
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Amantidine and Rimantidine
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Bind to M2 Protein that facilitates uncoating of Influenza A
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Olsetamavir and Zanamivir
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Nueraminidase Inhibitors that prevent virus spreading to other cells
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NRTIs
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Antiretroviral
Has sugar with no OH so they can't be added on to- chain terminates |
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NNRTIs: Efavirenz
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Large molecule doesn't resemble nucleotide but binds RT and sterically hinders DNA production
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Protease Inhibitors
Lopinavir, Atazanavir, Ritonavir |
Inhibits progression to mature virus
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Enfuvirtide
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Fusion inhibition
Corresponds to hydrophobic region of gp41 and blocks the conformational change that must occur for fusion |
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Raltegravir
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Integrase inhibitor that prevents HIV1 from incorporating into host genome
No viral protein is made |
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Miraviroc
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CCR5 Inhibitor
Hepatotoxic |
