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27 Cards in this Set
- Front
- Back
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MOA of Acyclovir
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Monophosphorylated by viral thymidine kinase
Inhibits viral DNA polymerase When incorporated into DNA it acts as a chain terminator -lacks the equivalent of ribosyl 3' OH group |
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Mechanism of resistance of acyclovir
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Lack of thymidine kinase
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Clinical use of Acyclovir
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HSV
VZV Reduces viral shedding in HSV |
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Side effects of Acyclovir
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Crystalluria (maintain full hydration)
NOT hematotoxic |
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Clinical use of Ganciclovir
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HSV
VZV **CMV** |
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Side effects of Ganciclovir
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Hematotoxicity
Crystalluria (maintain hydration) |
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MOA of Ganciclovir
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Needs phosphorylated by viral thymidine kinase
Inhibits viral DNA polymerase Causes chain termination |
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MOA of Foscarnet
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NOT A PRODRUG
-doesn't need phosphorylated Inhibits DNA and RNA polymerases |
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Clinical use of Foscarnet
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HSV, VZV, CMV
Acyclovir resistant strains of HSV |
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Side effects of Foscarnet
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Nephrotoxicity
Hypocalcemia -tremors and seizures |
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Zidovudine MOA
(NRTI) |
phosphorylated to a triphosphate that can inhibit reverse transcriptase to cause chain termination
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Side effects of Zidovudine
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Hematoxicity
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Side effects of Didanosine
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Pancreatitis
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Lamivudine
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Least toxic of the NRTIs
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Protease Inhibitors MOA
(avirs) |
Aspartate protease that cleaves precursor polypeptides in HIV buds to form the proteins of the mature virus core
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Side effects of Indinavir
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Protease Inhibitor
Crystalluria |
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Side effect of Ritonavir
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Protease Inhibitor
BOOSTS levels of other HIV drugs -inhibits P450s |
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Side effects of Protease Inhibitors (avirs)
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Insulin resistance
Central adiposity |
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MOA of Enfuvirtide
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Fusion inhibitor
binds gp41 |
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MOA of Maraviroc
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Fusion inhibitor
binds CCR5 |
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MOA of Amantadine
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Blocks attachment, penetration and uncoating of INFLUENZA A viur
-target is the M2 protein w/in the membrane |
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Clinical use of Amantadine
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Many prophylaxis of
influenza A Parkinsonism (causes the release of DA from pre-synpatic nerve) |
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Side effects of Amantadine
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Livedo reticularis
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MOA of Zanamivir and Oseltamivir
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Inhibits neuraminidases of influenza A and B
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Clinical uses of Zanamivir and Ostelamivir
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Prophylaxis mainly of Influenza A and B
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MOA of Ribavirin
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Prodrug
Triphosphate inhibits viral RNA polymerase |
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Clinical use of Ribavirin
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Adjunct to alpha-interferons in hepatitis C
Management of RSV |
