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24 Cards in this Set

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Isoniazid
MOA
Bacterstatic
MOA: inhibits of the biosynthesis of mycolic acids.
Resistance of Isoniazid
missense mutation inhA
Drug - Isoniazid
- Antacids interfere with absorption.
- exreted in urine
Adverse Effects of INH.
- Peripheal Neuropathy
- GI
- Increased liver enzymes
- Hepatitis
Rifampin act on what bugs:

BACTERICIDAL AGENT
- M. Bovis
- M. kansasii
- M. Tuberculosis

- S. mediterranei
Rifampin MOA:
- inhibits DNA - dependent RNA polymerase.
Resistance MOA for RIFAMPIN
- Mutations of the polymerase rpoB gene.
Excretion of the INH:
- BILE
- METABOLITE are active.
Adverse Effects of Rifampin
- Orange color sweat, etc.
- Flu-like syndrome
- induces drug metabolizm
- elevated liver enzymes
Organisms covered by rifabutin:
- MAC prophylaxis
- M. tuberculosis.
RIFAPENTINE: CI,
USED FOR OSE:
A.E: PORPHYRIA
dOSE: ONCE WEEKLY
lONG ACTING AGENT IN TB.
Ethambutol: bugs
M. tuberculosis
M. avium
BACTERIOSTATIC.
Ethambutol:
MOA:
RESISTANCE:
- Inhibits arabinosyl transferase.
- Resistance: signle a.a. changes in embA gene.
Excreted unchanged in the urine:
- glomerular filtration and tubular secretion
- excreted in the urine.
Pyrazinamide MOA:
- MOA: Target mycobacterial fatty acid synthase I gene in volved in mycolic acid biosynthsis.
Pyrazinamide excreted by:
glomerular filtration
A.E. OF pyrazinamide:
1. Liver toxicity
2. Hyperuricemia
3. GI distress
4. Arthralgia
Ethionamide MOA:
- mycolic acid synthesis inhibitor
- resistance when used alone
- excreted in the bile
Ethionamide ADVERSE EFFECTS:
Hypothroidism, glycemia, hepatitis

N/V
Anorexia, abdominal pain
Metallic taste
Aminosalicyclic Acid:
M. Tuberculosis
GI:
- Anorexia, Nausea, Abdominal Distress
- Diarrhea, Epigastric Pain.
Cycloserine: MOA
- Cell wall inhibitor
- inhibits alanine racemase
- ihhibits D-alanyl-D-alanine ligase.
Excretion of cycloserine:
- kidney, accumulates renal dysfunction
Capreomycin:
Polypeptide antibiotic
- excreted unchanged in the urine.
A.E. of Capreomycin:
1. Nephrotoxicity
2. Ototoxicity
3. Vestibular Toxicity
4. Partial NM Blockade.