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24 Cards in this Set
- Front
- Back
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Isoniazid
MOA |
Bacterstatic
MOA: inhibits of the biosynthesis of mycolic acids. |
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Resistance of Isoniazid
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missense mutation inhA
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Drug - Isoniazid
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- Antacids interfere with absorption.
- exreted in urine |
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Adverse Effects of INH.
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- Peripheal Neuropathy
- GI - Increased liver enzymes - Hepatitis |
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Rifampin act on what bugs:
BACTERICIDAL AGENT |
- M. Bovis
- M. kansasii - M. Tuberculosis - S. mediterranei |
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Rifampin MOA:
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- inhibits DNA - dependent RNA polymerase.
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Resistance MOA for RIFAMPIN
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- Mutations of the polymerase rpoB gene.
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Excretion of the INH:
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- BILE
- METABOLITE are active. |
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Adverse Effects of Rifampin
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- Orange color sweat, etc.
- Flu-like syndrome - induces drug metabolizm - elevated liver enzymes |
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Organisms covered by rifabutin:
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- MAC prophylaxis
- M. tuberculosis. |
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RIFAPENTINE: CI,
USED FOR OSE: |
A.E: PORPHYRIA
dOSE: ONCE WEEKLY lONG ACTING AGENT IN TB. |
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Ethambutol: bugs
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M. tuberculosis
M. avium BACTERIOSTATIC. |
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Ethambutol:
MOA: RESISTANCE: |
- Inhibits arabinosyl transferase.
- Resistance: signle a.a. changes in embA gene. |
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Excreted unchanged in the urine:
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- glomerular filtration and tubular secretion
- excreted in the urine. |
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Pyrazinamide MOA:
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- MOA: Target mycobacterial fatty acid synthase I gene in volved in mycolic acid biosynthsis.
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Pyrazinamide excreted by:
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glomerular filtration
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A.E. OF pyrazinamide:
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1. Liver toxicity
2. Hyperuricemia 3. GI distress 4. Arthralgia |
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Ethionamide MOA:
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- mycolic acid synthesis inhibitor
- resistance when used alone - excreted in the bile |
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Ethionamide ADVERSE EFFECTS:
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Hypothroidism, glycemia, hepatitis
N/V Anorexia, abdominal pain Metallic taste |
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Aminosalicyclic Acid:
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M. Tuberculosis
GI: - Anorexia, Nausea, Abdominal Distress - Diarrhea, Epigastric Pain. |
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Cycloserine: MOA
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- Cell wall inhibitor
- inhibits alanine racemase - ihhibits D-alanyl-D-alanine ligase. |
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Excretion of cycloserine:
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- kidney, accumulates renal dysfunction
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Capreomycin:
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Polypeptide antibiotic
- excreted unchanged in the urine. |
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A.E. of Capreomycin:
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1. Nephrotoxicity
2. Ototoxicity 3. Vestibular Toxicity 4. Partial NM Blockade. |
