Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
ethambutol |
Inhibits transfer of mycolic acids into cell wall of tubercle bacillus |
|
|
isoniazid |
Prodrug, which once activated, inhibits synthesis of mycolic acids (essential component bacterial cell wall) |
|
|
pyrazinamide |
Mechanism unclear. Metabolite (pyrazinoic acid) may lower intrabacterial pH to level that could inactivate vital target enzyme (e.g. fatty acid synthase. |
|
|
rifampicin |
inhibits DNA–dependent RNA polymerase activity in bacillus |
|
|
nystatin |
Binds to sterols in cell membrane of susceptible species, resulting in increased membrane permeability and subsequent leakage of intracellular components. |
|
|
aciclovir |
As triphosphate, competitively inhibits viral DNA polymerase and competes with natural deoxyguanosine triphosphate for incorporation into viral DNA, thus acting as chain terminator |
