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25 Cards in this Set
- Front
- Back
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Typical antipsychotics reduce:
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Positive Symptoms
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Dopamine Pathways:
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Mesolimbic
Mesocortical Nigrostriatal Tueroinfundibular Thalamic dopamine System |
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Dopamine deficits in the Mesocortical pathway:
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Lead to negative and cognitive symptoms
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DA deficits in the Nigrostriatal:
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Leads to extrapyramidal effects/
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Preferred first line tx for anxiety
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SSRI
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Antidepressants NOT good for anxiety?
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Wellbutrin
Norpramin |
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Buspar mechanism of action
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partial serotonin agonist
5HT1A receptors |
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Benefits of Buspar
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Safe to use with people with drug issues
Does not produce dependence or withdrawal Tolerated in elderly |
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Weird thing about Buspar
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So much is lost in the first pass of intake (90%) that it is nearly a placebo
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First drug approved for anxiety and depression
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Effexor
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Adrenergic effects of Buspar
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add
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Clonidine
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Used during detox
Blocks adrenergic effects, but not the subjective effects of anxiety |
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Effects of Benzodiazapines and Barbiturates?
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In order of dosage:
Sedation Hypnosis (sleep) Anesthesia Anticonvulsant Muscle relaxtion Depressed respiration Memory impairment Heart issues |
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Sedation effects:
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Suppresses response to stimulation
Decreases activity and ideation Behavioral disinhibition Impaired judgement Loss of self control |
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Sleep affects of benzo and barbit
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Decrease REM sleep
Decrease slow wave sleep Fall asleep easier |
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Memory impairment in benzos and barbis caused by
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Glutamate being depressed
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Ambien
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Helps you go to sleep but not stay asleep
Half life of 1.5-3.5 hours |
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Sonata
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Half life 1 hour
Increases effects of alcohol |
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Imovane
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Longer half life than Ambien
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GABAminergic drugs
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Ambien
Sonata Imovane Lunesta |
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GABAminergic effects
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Depress REM
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Benzodiazapines
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Diazepam (Valium)
Chlordiazapoxide (Librium) Clonazepam (Klonopin) Lorazepam (Ativan) Oxazepam (Serax) Alprazolam (Xanax) |
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Benzos and dementia
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Simulates dementia
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Valium and dementia
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Half life of two weeks
Must be out of the system before assessing fro dementia/cognitive issues |
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Benzo and CBT
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Not good combination
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