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5 Cards in this Set
- Front
- Back
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Classical Antipsychotics
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Low potency: Chlorpromazine, Thioridazine
Intermediate: Trifluoparazine, Perphenazine, Thiothixine High potency: Haloperidol, Fluphenazine |
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Chlorpromazine
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1st generation neuroleptic
Mechanism: D2 antagonist, alpha-1 antagonist; also muscarinic antagonist, H1 antagonist, channel blocker works in frontal cortex and limbic Clinical use: antipsychotic, sedation Side Effects: EPS, sedation, decreased seizure threshold, hypotension, neuroleptic malignant syndrome, galactorrhea/amenorrhea |
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Diphenhydramine
Trihexiphenidyl Benztropine |
Anticholinergic AntiParkinson Drugs
Treatment of early EPS |
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Clozapine
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Atypical Antipsychotic
Mechanism: DA antagonist, 5-HT2A antagonist, more anticholinergic than other antipscychotics Clinical Use: Refractory cases of psychosis (to classic therapy) Side effects: less EPS, 1-2% agranulocytosis, tremendous weight gain |
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Olanzapine
Risperidone |
Mechanism: same as Clozapine
Clinical Use: Schizo w/o blood dysrasia altho not as good as Clozapine in refractory cases Side Effects: some EPS and TD (less than first gen), hypotension, sexual dysfunction, neuroleptic malignant syndrome |
