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5 Cards in this Set

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Classical Antipsychotics
Low potency: Chlorpromazine, Thioridazine
Intermediate: Trifluoparazine, Perphenazine, Thiothixine
High potency: Haloperidol, Fluphenazine
Chlorpromazine
1st generation neuroleptic
Mechanism: D2 antagonist, alpha-1 antagonist; also muscarinic antagonist, H1 antagonist, channel blocker
works in frontal cortex and limbic

Clinical use: antipsychotic, sedation

Side Effects: EPS, sedation, decreased seizure threshold, hypotension, neuroleptic malignant syndrome, galactorrhea/amenorrhea
Diphenhydramine
Trihexiphenidyl
Benztropine
Anticholinergic AntiParkinson Drugs
Treatment of early EPS
Clozapine
Atypical Antipsychotic
Mechanism: DA antagonist, 5-HT2A antagonist, more anticholinergic than other antipscychotics

Clinical Use: Refractory cases of psychosis (to classic therapy)

Side effects: less EPS, 1-2% agranulocytosis, tremendous weight gain
Olanzapine
Risperidone
Mechanism: same as Clozapine

Clinical Use: Schizo w/o blood dysrasia altho not as good as Clozapine in refractory cases

Side Effects: some EPS and TD (less than first gen), hypotension, sexual dysfunction, neuroleptic malignant syndrome