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20 Cards in this Set

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  • Back
What is the role of G72?
G72 is an activator of DAAO
What is the role of DAAO?
DAAO metabolizes D-serine
What is the role of D-serine?
D-serine is an endogenous modulator of the NMDA receptor.
What is the role of neuregulin and where is it located?
Neuregulin affects NMDA receptors via actions on ErbB receptors and regulation of NMDA-receptor expression. It also has roles in neurodevelopment, promoting neuronal migration and cellular differentiation. Oh, and it is located in the glutaminergic synaptic vesicles.
What is the role of Dysbinin?
Dysbindin participates in the formation and maintenance of synapses.
What are the two classes of typical drugs?
Phenothiazines and Butyrophenones
What is the prototype phenothiazine and what is its potency?
Chlorpromazine, low potency
What is the prototype butyropherone and what is its potentcy?
Haloperidol; high potentcy
What is the treatment for acute dystonia (EPS)?
Antimuscarinic agents
What is the treatment for akathisia (motor restlessness)?
Reduce or change NL; antimuscarinics, benzodiazepines, or propanolol may help
Which drug is associated with causing Parkinsonism?
Fluphenazine
How is Parkinsonism treated?
antimuscarinics may help
How do the typical drugs act primarily?
Typical drugs act primarily at the DA (D2) receptors
What is the benefit of blocking D2 receptors and what are the possible side effects?
Benefit - antipsychotic effect and efficacy on positive symptoms; SEs - EPS and prolactin elevation
What is the benefit of blocking 5HT2A receptors and what are the possible side effects?
Benefit - fewer EPS; SEs- sexual dysfunction?
What is the mechanism of aripiprazole?
Aripiprazole is a partial agonist at D2 receptors and also partial agonist at 5HT1A & antagonist at 5HT2A receptors.
For what other diseases is haloperidol used?
Tourette's disorder and Huntington's disease
Which drugs are recommended for treating aggression/violence?
Haloperidol and Clozapine (Valproate as an adjunct)
What drugs are recommended for treating insomnia?
Atypicals or Chlorpromazine (benzodiazepine or trazodone, diphenhydramine as adjuncts)
What is the recommended treatment for excessive water drinking?
Clozapine