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20 Cards in this Set
- Front
- Back
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What is the role of G72?
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G72 is an activator of DAAO
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What is the role of DAAO?
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DAAO metabolizes D-serine
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What is the role of D-serine?
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D-serine is an endogenous modulator of the NMDA receptor.
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What is the role of neuregulin and where is it located?
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Neuregulin affects NMDA receptors via actions on ErbB receptors and regulation of NMDA-receptor expression. It also has roles in neurodevelopment, promoting neuronal migration and cellular differentiation. Oh, and it is located in the glutaminergic synaptic vesicles.
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What is the role of Dysbinin?
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Dysbindin participates in the formation and maintenance of synapses.
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What are the two classes of typical drugs?
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Phenothiazines and Butyrophenones
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What is the prototype phenothiazine and what is its potency?
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Chlorpromazine, low potency
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What is the prototype butyropherone and what is its potentcy?
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Haloperidol; high potentcy
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What is the treatment for acute dystonia (EPS)?
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Antimuscarinic agents
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What is the treatment for akathisia (motor restlessness)?
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Reduce or change NL; antimuscarinics, benzodiazepines, or propanolol may help
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Which drug is associated with causing Parkinsonism?
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Fluphenazine
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How is Parkinsonism treated?
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antimuscarinics may help
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How do the typical drugs act primarily?
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Typical drugs act primarily at the DA (D2) receptors
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What is the benefit of blocking D2 receptors and what are the possible side effects?
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Benefit - antipsychotic effect and efficacy on positive symptoms; SEs - EPS and prolactin elevation
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What is the benefit of blocking 5HT2A receptors and what are the possible side effects?
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Benefit - fewer EPS; SEs- sexual dysfunction?
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What is the mechanism of aripiprazole?
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Aripiprazole is a partial agonist at D2 receptors and also partial agonist at 5HT1A & antagonist at 5HT2A receptors.
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For what other diseases is haloperidol used?
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Tourette's disorder and Huntington's disease
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Which drugs are recommended for treating aggression/violence?
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Haloperidol and Clozapine (Valproate as an adjunct)
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What drugs are recommended for treating insomnia?
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Atypicals or Chlorpromazine (benzodiazepine or trazodone, diphenhydramine as adjuncts)
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What is the recommended treatment for excessive water drinking?
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Clozapine
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